Collaborative Observational Study of Myopia in COMET Children 2: Clinial Ceneter

描述（由申请人提供）：本提案要求阿拉巴马大学伯明翰临床中心继续按照COSMICC2方案，每年对目前入组的127名COSMICC参与者（自1997-98入组以来仅有5名受试者失去随访）进行额外5年（总随访14年）的检查。从该中心收集的数据将用于解决Chair申请中更详细描述的具体目标，并在此简要总结：1)使用数学函数（Gompertz函数和其他函数）对58%的COSMICC受试者的进行性近视进展进行建模，并基于先前确定的风险因素（年龄，种族，父母近视）建立预测模型和检验假设；2)在这一特征明确的近视队列中，检验与近视进展、稳定和轴向伸长相关的环境危险因素的4个假设；3)检验COSMICC受试者IOP、CCT和黄斑厚度发生近视相关变化的三个相关危险因素的假设。近视的高患病率（占美国成年人口的25%）及其作为公共卫生问题（可导致视力丧失和失明的危险因素）的突出地位强调了增加对潜在进展和最终稳定机制的了解的重要性，以便在未来近视可能被限制在低水平。更好地了解预测近视进展和稳定的因素也将有助于指导干预措施的选择和时机，以及针对那些可能从治疗中获益最多的群体。

DESCRIPTION (provided by applicant): This proposal is for the University of Alabama at Birmingham Clinical Center to continue to annually examine the 127 currently enrolled COSMICC participants (only 5 subjects are lost to follow-up since enrollment in 1997-98) for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address the specific aims described in more detail in the Chair application and summarized briefly here: 1) to use mathematical functions (the Gompertz function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia); 2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of myopes; and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment.