A Resource for Genetic Epidemiology Research in Adult Health and Aging

描述（由申请人提供）：这个“大机会”项目的目标是创建一个独特的和全面的人口为基础的资源，研究到常见的年龄相关疾病的遗传和环境基础及其治疗，以及影响健康老龄化和长寿的因素。拟议的资源将汇集成一个广泛访问的数据库，一个非常丰富的数据集，10万名参与者的研究计划基因，环境和健康（RPGEH），在北方加州（KPNC）的凯撒永久医疗保健计划。RPGEH包括来自KPNC的全面纵向电子病历的数据;具有人口统计学，行为和其他风险因素数据的参与者问卷;绘制环境暴露的地理信息系统（GIS）数据库（例如，空气和水的质量）和邻里特征与参与者的居住历史;以及使用Oragene试剂盒从所有参与者获得的唾液样本。RPGEH的100，000名参与者广泛同意将他们的DNA和其他数据用于研究遗传和环境对健康和疾病的影响。受试者的平均年龄为65岁，所有主要族裔群体都有很好的代表性。在这项提案中，我们特别要求提供资金，使用新的Affyestival GeneTitan基因分型系统将700，000个SNP和端粒长度测量的有价值的全基因组关联数据添加到资源中，以全面研究影响成人发病风险的遗传和环境因素及其治疗，以及健康老龄化。SNPs的选择将被定制，以便于检测新的关联，并跟踪以前确定的关联。KPNC保存的电子临床记录的纵向性质意味着，经过分析的表型数据可用于解决随着时间推移的健康和疾病问题。我们预计，这一资源将服务于国内和国际上大量研究人员的需求，以调查有关老龄化的复杂问题，无论是短期还是未来几年。 公共卫生相关性：这一“重大机会”项目的目标是建立一个独特和全面的人口资源，用于研究与年龄有关的常见疾病及其治疗的遗传和环境基础，以及影响健康老龄化和长寿的因素。拟议的资源将汇集一套关于100 000名参与者的极其丰富的数据，形成一个可广泛访问的数据库。拟议的项目将在综合电子健康记录的数据中添加70万个SNP的遗传数据和端粒长度数据;包含人口统计学，行为和其他风险因素数据的参与者问卷;地理信息系统（GIS）数据库，将环境暴露映射到参与者的居住历史。

DESCRIPTION (provided by applicant): The goal of this "Grand Opportunities" project is to create a unique and comprehensive population-based resource for research into the genetic and environmental basis of common age-related diseases and their treatment, and factors influencing healthy aging and longevity. The proposed resource will bring together into a broadly accessible database, an extraordinarily rich set of data on 100,000 participants in the Research Program on Genes, Environment and Health (RPGEH), based in the Kaiser Permanente Medical Care Plan in Northern California (KPNC). The RPGEH includes data from the comprehensive, longitudinal electronic medical records of KPNC; a participant questionnaire with demographic, behavioral, and other risk factor data; a geographic information system (GIS) database that maps environmental exposures (e.g., air and water quality) and neighborhood characteristics to participants' residential histories; and saliva samples obtained from all participants using Oragene kits. The 100,000 completed participants in RPGEH have broadly consented to have their DNA and other data used to conduct studies of genetic and environmental influences on health and disease. The average age of the subjects is 65 years, with good representation of all the major ethnic groups. In this proposal, we are specifically requesting funds to add valuable genome-wide association data for 700,000 SNPs and measures of telomere length to the resource using a novel Affymetrix GeneTitan genotyping system, to enable comprehensive studies of genetic and environmental factors that influence the risk of adult-onset diseases and their treatment, and healthy aging. The selection of SNPs will be customized to facilitate the detection of new associations and to follow up previously identified associations. The longitudinal nature of the electronic clinical records maintained by KPNC means that the phenotype data subject to analysis can be used to address questions of health and disease over time. We anticipate that this resource will serve the needs of a vast array of researchers both nationally and internationally to investigate complex questions regarding aging, both for the short term and for years to come. PUBLIC HEALTH RELEVANCE: The goal of this "Grand Opportunities" project is to create a unique and comprehensive population-based resource for research into the genetic and environmental basis of common age-related diseases and their treatment, and factors influencing healthy aging and longevity. The proposed resource will bring together into a broadly accessible database, an extraordinarily rich set of data on 100,000 participants. The proposed project will add genetic data on 700,000 SNPs and data on telomere length to data from comprehensive electronic health records; a participant questionnaire with demographic, behavioral, and other risk factor data; a geographic information system (GIS) database that maps environmental exposures to participants' residential histories.