The Effect of Salsalate on Insulin Action and Secretion

本研究是一项随机、安慰剂对照试验，采用胰岛素作用的金标准测量（正常血糖-高胰岛素钳夹技术）和胰岛素分泌（高血糖钳夹技术），检查短期双水杨酸（每天3克，持续7天）对胰岛素作用和分泌的影响。 在本研究期间，在干预之前和之后收集炎症的测量结果，以研究这些标记物的变化如何与胰岛素作用的变化相关。还在干预之前和之后收集单核细胞以测量NF-B活性，以具体研究IKK β途径在胰岛素作用中的作用。招聘工作于2008年2月完成。 一周后，接受双水杨酸的志愿者空腹血糖浓度较低，口服葡萄糖耐量试验中的葡萄糖曲线下面积较低，C反应蛋白浓度较低。在钳夹期间，接受双水杨酸的患者的葡萄糖输注速率也较高，但稳态胰岛素浓度也较高。考虑到胰岛素浓度的变化，安慰剂组和双水杨酯组之间的葡萄糖摄取没有差异。因此，双水杨酸改善胰岛素抵抗，但通过其对胰岛素清除的作用，而不是通过对胰岛素作用的直接作用。为了支持这一点，双水杨酸治疗没有降低NF-B活性。双水杨酸对胰岛素分泌的影响的结果目前正在等待中。

This study is a randomized, placebo controlled trial to examine the effects of a short course of salsalate (3 grams per day for 7 days) on insulin action and secretion, using gold standard measurements of insulin action, the euglycemic-hyperinsulinemic clamp, and insulin secretion, the hyperglycemic clamp technique. During this study measures of inflammation are collected prior to and following the intervention to investigate how changes in these markers are associated with changes insulin action. Monocytes are also collected prior and following the intervention to measure NF-B activity to specifically investigate the role of the IKK beta pathway in insulin action. Recruitment was completed in February, 2008. After one week, volunteers who received Salsalate had lower fasting plasma glucose concentrations, lower glucose area under the curve during an oral glucose tolerance test, and lower c-reactive protein concentrations. Glucose infusion rates during the clamp were also higher in those who received Salsalate, but so were steady state insulin concentrations. After accounting for the change in insulin concentration, there was no difference in glucose uptake between the placebo and Salsalate group. Therefore, Salsalate improves glycemia, but via its effect on insulin clearance, not via a direct effect on insulin action. In support of this, Salsalate treatment did not decrease NF-B activity. Results of the effect of Salsalate on insulin secretion are currently pending.