Comparative Medicine Core Facility Infrastructure Improvement

描述（由申请人提供）：美国卫生与公众服务部报告“2020：新愿景”强调再生医学是21世纪世纪医疗保健的先锋。从50年前的骨髓移植到最近的干细胞衍生器官移植，美国国立卫生研究院和国家科学院的专家分析认为再生医学是现代医学实践的新兴核心组成部分。该提案通过提出旨在建立再生医学产品和服务的增强措施，解决了核心设施运营的关键差距和需求，并调整了比较医学系的资源，以加速发现和转化到医学实践社区的融合。拟议加强生物安全2级设施和支持性稳定动物设施将促进围绕几个最先进的技术和特定领域科学平台建立的专门基础设施的全面协调，这些平台将把独立调查人员的联合体转变为一个高性能系统。马约诊所的比较医学部正在进行必要的资源战略调整，以支持发现，转化和应用到临床实践中。将加强质量管理系统，以确保最佳做法和综合工作流程。增强的基础设施、系统和流程以及科学整合将提供高性能的执行，这将大大有助于马约诊所的护理模式。

DESCRIPTION (provided by applicant): The U.S. Department of Health and Human Services report "2020: A New Vision" highlights that regenerative medicine is the vanguard of the 21st century healthcare. From bone marrow transplants five decades ago to the most recent stem cell-derived organ transplantations, the National Institutes of Health and National Academies expert analysis recognize regenerative medicine as an emerging core component of modern medical practice. The proposal addresses critical gaps and needs of the core facility operations by proposing enhancements designed to establish regenerative medicine products and services, and to align Department of Comparative Medicine resources to accelerate the convergence of discovery and translation into the medicine community of practice. The proposed enhancement of the Biosafety Level-2 facility and the supporting Stabile animal facility will facilitate a comprehensive coordination of specialized infrastructure built around several state-of-the-art technological and domain-specific scientific platforms that will transform the conglomerate of independent investigators into a high performance system. Mayo Clinic's Department of Comparative Medicine is engaged in a strategic realignment of resources necessary to support the discovery, translational and applications into the clinical practice. Quality Management Systems will be strengthened to ensure best practices and integrated workflow processes. The enhanced infrastructure, systems and processes, and scientific integration will provide high-performance execution that will contribute substantially to the Mayo Clinic Model of Care.