2023 International TSC Research Conference

2023年国际TSC研究大会的目标是(1)通过以下方式启发新的研究方向 暴露来自该领域以外的受训者和研究人员，并属于研究中代表性较低的群体 TSC或其他相关领域的最新研究进展，以及(2)鼓励合作研究，以 解决受TSC影响的人未得到满足的医疗需求以及相关疾病，包括癫痫、自闭症、 淋巴管肌瘤病(LAM)，以及表型重叠的罕见疾病。TSC是一种常染色体 显性遗传性疾病，其特征是由于突变导致许多器官的细胞生长异常 在TSC1或TSC2基因中。对于第一个目标，TSC联盟和组委会将(A) 在主要会议开始前的上午，主办为期半天的TSC早期职业研究研讨会；(B) 利用旅行奖励，将从提交的摘要中挑选出来的实习生和初级教员带到职业生涯的早期 研究人员研讨会和研究会议，与其他受训人员和早期研究人员接触 关于他们职业阶段特有的问题，在平台和海报演示中分享他们的数据，与 对他们的科学和演讲技巧的反馈，并让他们接触到更广泛的研究机会 (例如，行业、患者倡导)在TSC和相关疾病领域；和(C)增加 与会者保留一半的旅行奖项给属于代表人数不足的群体的科学家 研究，包括没有数据介绍TSC相关工作的科学家。朝着第二个目标， 会议将(A)将非TSC重点的研究人员和TSC专家聚集在一个环境中 有利于共享数据、建立网络并为未来协作创造机会；(B)利用突破 讨论相关跨学科专题的会议；(C)利用平台会议专门促进 跨专业的理解--在合理可能的范围内--在同一节课中结合基本的、 翻译和临床研究数据。确保提出的概念与以前的概念有意义地不同 会议上，12位受邀演讲者中没有一位是TSC联盟赞助的2021年虚拟大会的特邀演讲者 或者2019年面对面的国际TSC研究会议，只有一次是最近的特邀演讲者 由英国TSC协会和LAM基金会主办的会议。以确保新的个体 参与塑造2023年会议，83%(12人中的10人)和25%(12人中的3人) 组委会甚至没有参加由台积电联盟主办的2021年虚拟或2019年面对面 国际TSC研究会议。为了促进研究人员与患者的互动，教育 TSC患者和/或护理人员的会议将于周六在研究所在的同一家酒店举行 会议。近距离的距离使研究人员能够在用餐时与患者互动，并在1小时的联合 包括患者在内的会议将于周六结束研究会议，让患者有机会 听取国际TSC调查人员的关键研究，并向他们提问。

The goals of the 2023 International TSC Research Conference are to (1) inspire new research directions by exposing trainees and researchers from outside the field and belonging to groups underrepresented in research to the latest research developments in TSC or other relevant fields, and (2) stimulate collaborative research to address unmet medical needs of those affected by TSC as well as related disorders, including epilepsy, autism, lymphangioleiomyomatosis (LAM), and rare diseases with overlapping phenotypes. TSC is an autosomal dominant genetic disorder characterized by abnormally regulated cell growth in many organs due to a mutation in either of the TSC1 or TSC2 genes. Toward the first goal, the TSC Alliance and organizing committee will (a) sponsor a half-day TSC Early Career Research Symposium the morning before the main conference begins; (b) utilize travel awards to bring trainees and junior faculty selected from submitted abstracts to the Early Career Researcher Symposium and research conference to engage with other trainees and early-stage investigators regarding issues unique to their career stage, share their data in platform and poster presentations with feedback on their science and on their presentation skills, and expose them to broader research opportunities (e.g., industry, patient advocacy) in the field of TSC and related disorders; and (c) increase the diversity of attendees by reserving half of the travel awards for scientists who belong to underrepresented groups in research, including scientists without data to present on TSC-related work. Toward the second goal, the conference will (a) assemble non-TSC-focused researchers together with TSC experts in an environment conducive to sharing data, networking, and building opportunities for future collaboration; (b) utilize breakout sessions to discuss relevant interdisciplinary topics; and (c) employ platform sessions specifically to facilitate cross-specialty understanding by combining in the same session—to the extent reasonably possible—basic, translational, and clinical research data. To ensure concepts presented differ meaningfully from previous conferences, none of the 12 invited speakers were invited speakers at the TSC Alliance-sponsored 2021 virtual or 2019 in-person International TSC Research Conferences, and only one was an invited speaker at recent conferences sponsored by the UK TSC Association and The LAM Foundation. To ensure new individuals are involved in shaping the 2023 conference, 83% (10 of 12) of the invited speakers and 25% (3 of 12) of the organizing committee did not even attend the TSC Alliance-sponsored 2021 virtual or 2019 in-person International TSC Research Conferences. To facilitate interaction of researchers with patients, an educational meeting for patients with TSC and/or caregivers will be held on Saturday in the same hotel as the research conference. The close proximity enables researchers to interact with patients at meals, and a 1-hour joint session including patients will conclude the research conference on Saturday, giving patients an opportunity to hear about key research from, and ask questions of, international TSC investigators.