Precision Rehabilitation Research for Children with Neuromotor Conditions (APTA Academy of Pediatric Physical Therapy Research Summit 6)

摘要 儿童康复的需求是巨大的，数字表明，330万美国儿童患有 持续需要康复治疗，110万人有持续的行动障碍，另有1 100万人受伤后需要康复以恢复功能。我们能够从传统的 康复的反复试验和错误过程（评估-治疗-重新评估-调整）已经变得复杂， 在患者之间选择结果和治疗方案的不一致性，并不令人惊讶， to wide宽variable可变性in outcomes结果.实施精准医疗让身体康复远离 “一刀切”和试错疗法，而是采用个性化的方法 通过考虑遗传和表观遗传的影响以及健康的社会决定因素， “在正确的时间，对正确的人进行干预。本次会议赠款提案寻求支持， 美国物理治疗协会儿科学会（APTA）研究峰会6（RS6）会议 小儿科），“精确康复研究的儿童神经运动条件。”跨越密集型 1-一整天和两天半的时间，RS6将是第一次会议，在儿科物理康复致力于 精准康复它将利用APTA儿科之前五项研究的成功记录 首脑会议迄今已从联邦和基金会获得1 500多万美元的后续资金 源实施精准医学方法进行儿科身体康复的关键是 代表了科学家、临床医生和父母/儿童的不同群体。RS6会议将包括 跨学科讲座，主旨演讲，护理人员/消费者和赞助/资助小组，大型和 小组讨论和独特的网络机会，以实现我们提出的目标[1]， 跨学科和教学内容，以支持精准医学的儿科物理翻译 康复，[2]确定目前的知识差距和关键的研究挑战，以促进 儿科精确康复，[3]促进儿科精确康复研究的发展。资金 该奖项将补充已经从APTA儿科获得的资金支持， 会议的要点和RS6提交的最多4个后续试点/规划研究赠款 参与者要求NICHD和NINDS提供补充支持，以确保RS6的多样性。 内容和出席情况，包括支持更多的发言者和提供津贴以支持参与 从学生谁确定为一个少数群体或小组的成员。除了培养新的 在儿科精确康复方面的合作，RS6的主要成果是开发一个可复制的模型 在整个生命周期内进行精确康复，并在各学科之间传授一套通用的术语。

ABSTRACT The need for rehabilitation in children is immense, with figures suggesting that 3.3 million US children have an ongoing need for rehabilitation therapy, 1.1 million have persistent mobility impairments, and an additional 1 million need rehabilitation to restore function after injury. Our ability to generate evidence from the traditional iterative trial and error process of rehabilitation (evaluate–treat–re-evaluate–adjust) has been complicated by inconsistency in the selection of outcomes and treatment regimens across patients, and not surprisingly, has led to wide variability in outcomes. Implementation of precision-medicine to physical rehabilitation moves away from both “one-size-fits-all” and trial-and-error approaches to therapy and instead embraces a personalized approach by considering genetic and epigenetic influences and social determinants of health to match “the right intervention, at the right time, to the right individual.” This conference grant proposal seeks support for the Research Summit 6 (RS6) meeting of the American Physical Therapy Association Academy of Pediatrics (APTA Pediatrics), “Precision Rehabilitation Research for Children with Neuromotor Conditions.” Spanning an intensive 1-full and 2-half day period, RS6 will be the first conference in pediatric physical rehabilitation dedicated to precision rehabilitation. It will leverage the strong record of success of APTA Pediatrics' previous five research summits that have resulted in over $15 million in subsequent funding to date from federal and foundation sources. Critical to the implementation of a precision medicine approach to pediatric physical rehabilitation is representation of a diverse cohort of scientists, clinicians, and parents/children. The RS6 meeting will include interdisciplinary lectures, a keynote address, caregiver/consumer and sponsorship/funding panels, large and small group discussions, and unique networking opportunities to achieve our proposed aims of [1] providing interdisciplinary and didactic content to support the translation of precision medicine to pediatric physical rehabilitation, [2] identifying current gaps in knowledge and critical research challenges necessary to advance pediatric precision rehabilitation, and [3] fostering growth of pediatric precision rehabilitation research. Funds from this award will complement monetary support already procured from APTA Pediatrics that will fund the essentials of the meeting and up to 4 subsequent pilot/planning research grants submitted by RS6 participants. Supplemental support is requested from NICHD and NINDS which will ensure diversity in both RS6 content and attendance, including supporting additional speakers and providing stipends to support participation from students who identify as a member of a minority group or subgroup. In addition to cultivating novel collaborations in pediatric precision rehabilitation, the main outcomes of RS6 are to develop a replicable model of precision rehabilitation over the lifespan and impart a common set of terminology among disciplines.