2023 Central Nervous System Injury and Repair Gordon Research Conference and Seminar

项目总结： 2023年戈登研究会议(GRC)系列会议题为“中枢神经系统损伤与修复”，连同随之而来的戈登研究研讨会(GRS)，将汇集各级互动研究人员，讨论中枢神经系统损伤、再生和修复方面的进展和挑战，特别是脊髓损伤。脊髓损伤是一项重大的医学挑战，因为它导致全球数百万人瘫痪，失去知觉，心肺功能障碍，膀胱和性功能障碍，以及终身疼痛。尽管多年来的努力，仍然缺乏有效的治疗方法。这在一定程度上是由于这种疾病的复杂性，除了轴突受损外，脊髓损伤还会导致细胞和分子环境的深刻变化，涉及神经元、胶质细胞、免疫细胞和其他细胞类型。一个新的共识是，针对损伤反应的多个细胞和分子方面的组合方法将是治疗脊髓损伤和诱导功能恢复所必需的。在这次会议上，我们将展示这一领域最令人兴奋和最前沿的科学进展，目标是集体加速发现和转化将导致功能恢复的治疗方法。会议演讲者涵盖了广泛的主题，从动物模型中神经元回路和轴突损伤的基本机制、临床应用和干细胞编程的进展，一直到临床实践和患者护理。将在正式的科学会议和非正式的海报会议上鼓励讨论，并为社会互动留出时间。随附的GRS将为学员提供一个互动论坛，交流他们的研究成果，并扩大他们的同行网络。GRC还将举办一个Power Hour，向所有与会者开放，讨论我们面临的挑战，特别是女性、代表性不足的少数族裔、弱势研究人员和受训者。我们预计将有大量基础科学家和内科科学家出席，以及来自工业界的代表。我们还预计，跨性别、种族、残疾、年龄和地理位置的多样性将确保科学内容的广泛和包容的传播。

Project Summary: The 2023 Gordon Research Conference (GRC) series, entitled “Central Nervous System Injury and Repair”, together with its accompanying Gordon Research Seminar (GRS), will bring together interactional researchers at all levels to discuss progress and challenges for CNS injury, regeneration, and repair, with particular emphasis on spinal cord injury. Spinal cord injury is a major medical challenge since it leaves millions of people worldwide paralyzed and with loss of sensation, cardiorespiratory, bladder, and sexual dysfunction as well as pain for their lifetime. Despite many years of efforts, effective treatment remains lacking. This is in part due to the complexity of this disease where in addition to the damage of axons, spinal cord injury leads to profound changes in the cellular and molecular environment, involving neurons, glia, immune cells, and other cell types. An emerging consensus is that combinatorial approaches targeting multiple cellular and molecular aspects of the injury response will be necessary to treat spinal cord injury and induce functional recovery. At this conference, we will showcase the most exciting and cutting-edge scientific progress in this field, with the goal of collectively accelerating the discovery and translation of treatments that will lead to functional recovery. The conference speakers cover broad topics from basic mechanisms in neuronal circuitry and axonal injury in animal models, clinical application, and progress in stem cell programming, through to clinical practice and patient care. The discussion will be encouraged both formally in the scientific sessions and informally during poster sessions and time set aside for social interactions. The accompanying GRS will serve as an interactive forum for trainees to communicate their research and broaden their peer network. The GRC will also feature a Power Hour, open to all attendees, to discuss challenges we face, particularly women, underrepresented minorities, disadvantaged researchers, and trainees. We expect a large attendance from basic and physician-scientists, as well as representation from industry. We also anticipate a breadth of diversity across gender, ethnicity, disability, age, and geographical location that will ensure a broad and inclusive communication of the scientific content.