2023 Elastin, Elastic Fibers and Microfibrils Gordon Research Conference and Gordon Research Seminar

项目总结/摘要 弹性蛋白、弹性纤维和相关的微纤维在动脉、韧带、肺和皮肤中特别丰富 而且在肌腱、眼睛和骨骼中也很重要。弹性蛋白是人类中寿命最长的蛋白质之一。它 在发育和生长过程中沉积和交联，然后在一段时间内保持代谢稳定。 辈子弹性蛋白纤维是独特的，因为它们为动态组织提供弹性，而且还提供弹性，即，他们 在生理力下变形，随后释放储存的能量以驱动被动反冲。这 会议将提供弹性组织生物学的深入报道，并将包括以下内容：分子 弹性蛋白的性质;弹性蛋白和微纤维组装;弹性蛋白在调节细胞信号传导中的作用;机械传感 弹性蛋白/微纤维-平滑肌细胞局灶性粘连;含弹性蛋白组织的老化;多组学和 用于弹性纤维系统分析的其他技术;由基因编码突变引起的遗传疾病 弹性纤维中的蛋白质或与弹性纤维相关的蛋白质;弹性组织的生物工程;以及将研究转化为 对破坏含弹性蛋白组织的疾病的改进治疗。会议的目的是 提供一个包容性的环境和时间，让多学科和不同的科学家聚集在一起， 相互作用，以催化弹性蛋白生物学的研究和新的合作;推动转化研究， 在诊断、管理和治疗获得性和遗传性疾病方面的突破， 弹性纤维和微纤维;促进来自不同背景的年轻科学家早日融入 弹性蛋白科学界;解决弹性蛋白生物学中数据的严谨性和可重复性相关问题 提供信息和互动，以推动弹性蛋白相关领域和科学的多样性。的 2023年弹性蛋白，弹性纤维和微纤维戈登研究会议将集中在最近的小说，未发表 该领域的发展，并将激发参与者的讨论，合作和新的假设 来自不同的学科和背景。随附的戈登研究研讨会将提供 实地受训人员可以与现有调查人员互动，展示他们的数据，并学习新的职业 发展技能。

Project Summary/Abstract Elastin, elastic fibers, and associated microfibrils are particularly abundant in arteries, ligaments, lungs, and skin but are also important in the tendons, eyes, and bone. Elastin is one of the longest-lived proteins in humans. It is deposited and cross-linked during development and growth, and then it remains metabolically stable over a lifetime. Elastin fibers are unique because they provide resilience to dynamic tissues but also elasticity, i.e., they deform under physiological forces and subsequently release stored energy to drive passive recoil. This conference will provide in-depth coverage of elastic tissue biology and will include the following: molecular properties of elastin; elastin and microfibril assembly; role of elastin in regulating cell signaling; mechanosensing of the elastin/microfibril-smooth muscle cell focal adhesions; aging of elastin-containing tissues; multi-omics and other technologies for elastic fiber system analyses; genetic diseases caused by mutations in genes encoding proteins in or associated with elastic fibers; bioengineering of elastic tissues; and translation of research to improve treatment of diseases that disrupt elastin-containing tissues. The aims of the conference are the following: Provide an inclusive environment and time for multidisciplinary and diverse scientists to gather and interact to catalyze research and new collaborations in the elastin biology; Drive translational research and breakthroughs in the diagnosis, management, and treatment of acquired and genetic disorders that involve elastic fibers and microfibrils; Promote the early integration of young scientists from diverse backgrounds into the elastin scientific community; Address issues related to rigor and reproducibility of data in the elastin biology field; Provide information and interaction to drive diversity in elastin-related field and science in general. The 2023 Elastin, Elastic Fibers & Microfibrils Gordon Research Conference will focus on recent novel, unpublished developments in the field and will stimulate discussions, collaborations, and novel hypotheses by participants from diverse disciplines and backgrounds. The accompanying Gordon Research Seminar will provide the trainees in the field a space to interact with established investigators, present their data, and learn new career development skills.