Regulation of T lymphocyte immunology to influenza virus

描述（由申请方提供）：流感感染仅限于肺上皮，其控制取决于有效的局部T淋巴细胞应答等因素。保护性免疫与流感特异性记忆T淋巴细胞相关，这些T淋巴细胞在气道中持续很长一段时间。因此，T淋巴细胞募集对于流感的保护和记忆至关重要。淋巴细胞迁移的控制是一个复杂的过程，由多种机制介导，包括选择素，整合素和趋化因子，它是由早期炎症信号精心策划的。然而，在原发性流感感染期间介导T淋巴细胞募集到感染部位的早期先天性细胞因子尚未得到很好的表征。该项目的总体目标是确定在流感病毒感染开始时决定CD8 T淋巴细胞募集的分子机制。首先，我们将确定在流感感染期间调节CD8 T细胞募集和功能的机制。其次，我们将根据这些信息来确定这一过程如何在肺中调节，以及它如何影响对流感感染的保护。为了开发更有效的流感治疗和疫苗，我们必须更好地了解流感感染期间调节肺部细胞介导的免疫的机制。

DESCRIPTION (provided by applicant): Influenza infection is confined to the lung epithelium and its control depends, among other factors, upon an effective local T lymphocyte response. Protective immunity is correlated with influenza-specific memory T lymphocytes that persist in the airways for extended periods of time. Thus, T lymphocyte recruitment is central for protection and memory to influenza. Control of lymphocyte migration is a complex process mediated by several mechanisms including selectins, integrins and chemokines, and it is orchestrated by early inflammatory signals. However, the early innate cytokines that mediate the recruitment of T lymphocytes during primary influenza infection to the site of infection are not well characterized. The overall goal of this project is to identify the molecular mechanisms that dictate CD8 T lymphocyte recruitment at the onset of infection with influenza virus. First, we will identify the mechanisms that regulate CD8 T cell recruitment and function during influenza infection. Second, we will build on this information to determine how this process is regulated in the lung and how it impacts protection against influenza infection. To develop more effective influenza treatments and vaccines, it is essential that we have a better understanding of the mechanisms that regulate cell-mediated immunity in the lung during influenza infection.