INIA-STRESS: Informatics and Analysis Core

描述（由申请人提供）：信息学和分析核心（BINFO）将提供几个不同的功能，以服务于nia -压力研究人员和项目。由于植物胁迫研究项目的范围和多样性，生物信息库的一般作用将是在研究项目之间提供标准化的研究支持和关键的综合功能。BINFO将为实验设计、高级统计分析、数据仓库或数据库存储以及高级生物信息学分析提供支持，包括开发或适应用于基因网络分析的新算法。BINFO包括四个不同机构（弗吉尼亚联邦大学、橡树岭国家实验室、田纳西大学诺克斯维尔分校和范德比尔特大学）的研究人员，并将根据不同的学科和涉及多个站点的专业知识划分为子核心。BINFOC的核心和相关目标是：1)提供一个基于网络的信息系统（www.iniastress.org），该系统将同时具有公共和ia - stress限制功能；2)为所有nia - stress项目提供先进的实验设计和统计支持；3)为跨INIA-Stress数据集的基因网络注释（INIAGestalt）分析和基因网络整合提供算法和辅助；4)为nia - stress微阵列实验设计、分析和数据库管理提供专业知识和工具。总之，BINFO将为本提案所有主要项目的数据集成和高级数据分析提供一个论坛。此外，BINFO提供的工具和资源将为酒精研究界和其他生物医学研究人员提供服务。

DESCRIPTION (provided by applicant): he Informatics and Analysis Core (BINFO) will provide several distinct functions to serve INIA-Stress investigators and projects. Because of the scope and diversity of INIA-Stress research projects, the general role of the BINFO will be to provide standardized research support and key integrative functions among the research projects. The BINFO will provide support for experimental design, advanced statistical analysis, data warehousing or database storage, and advanced bioinformatics analysis, including development or adaptation of novel algorithms for analysis of gene networks. The BINFO encompasses investigators at four different institutions (Virginia Commonwealth University, Oak Ridge National Laboratory, University of Tennessee at Knoxville and Vanderbilt University) and will be divided into subcores based upon different disciplines and involve expertise from multiple sites. The subcores and related aims of the BINFOC are: 1) Provide a web-based information system (www.iniastress.org) that will have both public and INIA-Stress restricted functions; 2) Provide advanced experimental design and statistical support for all INIA-Stress projects; 3) Provide algorithms and assistance for gene-network annotation (INIAGestalt) analysis and gene network integration across INIA-Stress datasets; and 4) Provide expertise and tools for experimental design, analysis and database management of microarray experiments for INIA-Stress. Altogether the BINFO will provide a forum for both data integration and advanced data analysis across all the primary projects of this proposal. In addition, the tools and resources provided by the BINFO will provide service to the alcohol research community and other biomedical researchers.