Octapeptin-based Antibiotics Against Multi-drug Resistant Gram-negative Bacteria

传染病是导致死亡的主要原因，社区和医院出现“超级细菌”令人严重关注。我们复活了一种20世纪70年代被遗忘的抗生素，它可以杀死引起肺炎、皮肤和尿路感染的超级细菌，这些疾病导致今天成千上万的澳大利亚人死亡和不适。我们将确定原始抗生素如何对抗超级细菌，并利用这些信息为未来设计更好的药物。

Infectious disease is a leading cause of death, and the emergence of "superbugs" in the community and hospitals is of grave concern. We have resurrected a ‘forgotten’ antibiotic from the 1970s that kills superbugs causing pneumonia, skin and urinary track infections; diseases that cause death and discomfort for thousands of Australians today. We will determine how the original antibiotic works against superbugs, and use this information to design better drugs for the future.