Novel approaches to understanding mental disorder, substance abuse and HIV-risk a

描述（由申请人提供）：此[修订后的] R21申请寻求两年的支持，以开发最先进的科学方法，以解决无家可归妇女现有研究中的四个重要差距：1）捕捉流动和难以接触的人口中的情况多样性; 2）增加我们对精神和物质使用障碍的了解（特别是人格障碍）在无家可归的妇女的多样性; 3）通过开发一个创新的事件历史日历的方法，提高我们对无家可归的理解轨迹;（4）提高对无家可归妇女的健康和艾滋病毒风险的认识，按情况和无家可归的轨迹分类。这项研究将提供测量发展和初步研究的多个国家的纵向R 01，旨在促进我们的理解无家可归的妇女，他们的运动和无家可归的精神和物质使用障碍，无家可归的妇女和未成年儿童在他们的监护下的后果，妇女的健康，艾滋病毒的风险，和艾滋病毒检测行为。计划中的纵向研究将侧重于不断增长但知之甚少的全国最弱势妇女群体。这一R21发展应用程序的具体目标是：（1）制定和试行一项抽样计划，以更好地反映无家可归妇女的多样性;（2）制定和试行一项创新性的事件历史日历，供无家可归妇女使用;（3）编制和试行轴1（UM-CIDI）和轴2（DIPD-IV）诊断性访谈时间表，以便在计算机辅助下对无家可归妇女进行个人访谈; 4）制定和规划妇女健康和艾滋病毒风险措施; 5）在中西部两个城市的200名无家可归妇女中试行这些措施。公共卫生相关性：这个[修订后的] R21发展应用程序将为无家可归妇女的第一个多州纵向诊断研究奠定基础。它建立在十多年难以接触无家可归人口的工作和之前对无家可归青少年的三年纵向诊断研究的基础上。这项申请将资助专门针对这一未得到充分研究的人口制定创新措施和抽样技术，并资助在中西部两个城市对200名无家可归妇女进行抽样的试点措施。

DESCRIPTION (provided by applicant): This [revised] R21 application seeks two years of support to develop state-of-the-science methodologies to address four important gaps in existing research with homeless women: 1) capture the diversity of circumstances among a fluid and hard-to-access population; 2) increase our understanding of mental and substance use disorders (particularly personality disorders) across the diversity of homeless women; 3) improve our understanding trajectories to homelessness through development of an innovative event history calendar approach; and 4) advance knowledge of homeless women's health and HIV-risk by circumstance and trajectories to homelessness. This research will provide measurement development and preliminary studies for a multi-state longitudinal R01 designed to advance our understanding of mental and substance use disorders among homeless women, their movement into and out of homelessness, the consequences of homelessness for women and minor children in their custody, and women's health, HIV-risk, and HIV testing behaviors. The planned longitudinal research will focus on a growing but poorly understood population of the nation's most vulnerable women. The specific aims of this R21 developmental application are to 1) develop and pilot a sampling plan that will better reflect the diversity of homeless women; 2) develop and pilot an innovative events history calendar for use with homeless women; 3) program and pilot Axis 1 (UM-CIDI) and Axis II (DIPD-IV) diagnostic interview schedules for computer-assisted personal interviews with homeless women; 4) develop and program women's health and HIV-risk measures; and 5) pilot the measures with 200 homeless women in two Midwestern cities. PUBLIC HEALTH RELEVANCE: This [revised] R21 developmental application will set the stage for the first multi-state longitudinal diagnostic study of homeless women. It builds on more than a decade of work with hard to access homeless populations and a prior three-year longitudinal diagnostic study of homeless adolescents. This application will fund the development of innovative measures and sampling techniques specifically for this understudied population and for the piloting of measures with a sample of 200 homeless women in two Midwestern cities.