Nutritional Epidemiology of Lower Urinary Tract Symptoms

描述（由申请人提供）：本项目利用作为波士顿地区社区卫生（BACH）研究的一部分收集的饮食数据，以帮助填补在不同的、随机的社区样本中泌尿妇科症状营养流行病学方面的知识空白。下尿路症状（LUTS），包括尿潴留、排尿和排尿后症状，是日常困扰和负担的来源，严重降低了数百万成年人的生活质量——仅在美国就有3000多万男性和女性。曾经盛行的范式认为这些症状是衰老不可避免的方面，不受生活方式选择的改变的影响，必须受到挑战，这项研究回应了全国范围内的研究呼吁，以确定这些症状的风险因素。饮食是最容易改变的生活方式因素之一，它具有非常合理的机制，可以缓解和预防LUTS，也可以参与LUTS的开始和发展，即每天消耗的营养和饮料。本研究分别考察了男性和女性碳水化合物、蛋白质、脂肪类型、钠、胆固醇、维生素C、维生素A、类胡萝卜素、钙和锌的摄入量与LUTS、排尿症状、排尿后症状和储存症状（包括尿急和尿失禁）之间的横断面和纵向关联。它还检查了膳食与补充来源的微量营养素以及不同摄入类别的剂量反应趋势。各种饮料的摄入量也被前瞻性地检查，以验证关于咖啡因、酸性或碳酸饮料影响的轶事证据。BACH获得了一个完整的、经过验证的饮食评估，该评估考虑了食物消费的种族差异，再加上关于泌尿系统症状、社会人口统计学、人体测量学、健康状况、药物和补充剂使用的深入数据，为开展营养和饮料在男性和女性泌尿系统症状中的作用的多变量分析提供了一个独特的、具有成本效益的机会。与公共卫生有关：项目简介：本研究将采用横断面和前瞻性队列研究设计方法，在以不同人群为基础的男性和女性样本中调查宏量营养素、微量营养素、液体和下尿路症状摄入之间的关系。下尿路症状将被全面检查，也被归类为储存症状，包括尿急和尿失禁、排尿症状和排尿后症状。

DESCRIPTION (provided by applicant): This project utilizes dietary data that was collected as part of the Boston Area Community Health (BACH) study to help fill knowledge gaps in the nutritional epidemiology of urogynecologic symptoms in a diverse, random community-based sample. Lower urinary tract symptoms (LUTS), including storage, voiding and post micturition symptoms, are a source of daily bother and burden and profoundly lower the quality of life of millions of adults - over 30 million men and women in the US alone. The once prevailing paradigm that these symptoms are an inevitable aspect of aging, unaffected by modification of lifestyle choices, must be challenged, and this study responds to nation-wide calls for research to identify risk factors for these symptoms. One of the most readily modifiable lifestyle factors that holds highly plausible mechanisms of offering relief and prevention, as well as being involved in the initiation and progression, of LUTS is diet - i.e., the nutrients and beverages consumed daily. This study examines the cross-sectional and longitudinal associations between intakes of carbohydrate, protein, types of fat, sodium, cholesterol, vitamin C, vitamin A, carotenoids, calcium and zinc, and LUTS, voiding symptoms, post micturition symptoms, and storage symptoms, including urgency and urinary incontinence, separately in men and women. It also examines dietary versus supplemental sources of micronutrients and dose-response trends across categories of intake. Intakes of various beverage types are also examined prospectively to verify anecdotal evidence regarding effects of caffeine, acidic or carbonated beverages. BACH obtained a complete validated dietary assessment that takes into account ethnic variation in food consumption, which, together with in-depth data on urologic symptoms, sociodemographics, anthropometrics, health status, medication and supplement usage, provides a unique cost-efficient opportunity to conduct multivariate analyses of the role of nutrients and beverages in urologic symptoms among men and women. PUBLIC HEALTH RELEVANCE: 7. PROJECT NARRATIVE This study will investigate the associations between intakes of macronutrients, micronutrients, fluids and lower urinary tract symptoms in a diverse, population-based sample of men and women using both cross- sectional and prospective cohort study design methodologies. Lower urinary tract symptoms will be examined both overall and also grouped as storage symptoms, including urgency and urinary incontinence, voiding symptoms, and post micturition symptoms.