9.4 Tesla Magnetic Resonance Imaging Scanner

描述（由申请人提供）：为达特茅斯学院和达特茅斯希区柯克医疗中心（DHMC）的高分辨率9.4T磁共振（MR）扫描仪提供资金，以服务和加快体内动物研究。美国国立卫生研究院资助的将利用磁共振扫描仪的研究项目如下：a)癌症成像：肿瘤氧合和治疗反应评估b)神经成像：脑血流动力学和脑损伤c)心脏成像：心脏血管生成和新生血管功能达特茅斯的这些研究项目得到了美国国立卫生研究院及其分支机构对上述项目的广泛支持。这些项目的共同点是，它们需要非侵入性成像技术来评估常见人类疾病的动物模型体内的解剖、生理和生物化学。磁共振成像（MRI）不仅提供了一个非侵入性的身体解剖窗口，而且同时揭示了器官功能的中心参数信息，包括血流（或灌注）、血液和组织氧合（用于估计氧代谢）。与磁共振波谱（MRS）相辅相成，获得了中央组织代谢物的数据，包括高能磷酸盐和乳酸，pH值和氨基酸神经递质。MRI也提供了巨大的潜力，通过使用标记的目标特异性探针在分子水平上成像组织。这些项目已被证明具有转化潜力。

DESCRIPTION (provided by applicant): Funding is requested for a high resolution 9.4T magnetic resonance (MR) scanner to serve and expedite in vivo animal research at the Dartmouth College and Dartmouth Hitchcock Medical Center (DHMC). The NIH funded research programs that will exploit the MR scanner are as follows: a) Cancer imaging: tumor oxygenation and assessment of treatment response b) Neuro-imaging: Cerebral haemodynamics and Brain injury c) Cardiac imaging: Angiogenesis in the heart and function of neovasculature These research programs in Dartmouth have extensive support from NIH and its subsections for the projects above. Common denominator for these projects is that they require non-invasive imaging technology for the assessment of anatomy, physiology and biochemistry in vivo in animal models for common human diseases. Magnetic resonance imaging (MRI) not only provides a non-invasive window to body anatomy, but at the same reveals information from central parameters of organ function, including blood flow (or perfusion), blood and tissue oxygenation (to estimate oxygen metabolism). Complemented with magnetic resonance spectroscopy (MRS), data from central tissue metabolites, including high-energy phosphates and lactate, pH and amino acid neurotransmitters, are obtained. MRI provides also great potentials to image tissue at molecular level by using tagged target specific probes. These projects have proven translational potential. PUBLIC HEALTH RELEVANCE The research projects in this proposal are dealing with several public health burdens in the US, including cancer, brain traumas and cardiovascular diseases. The requested high field MR scanner will greatly advance understanding of basic mechanisms of these common diseases. It will also greatly contribute to the efforts of improving diagnosis of these conditions and thereby, it is expected to aid planning for personalized treatment protocols. The MR scanner will expedite assessment of novel cancer and anti-ischemia treatment protocols in animal models. The requested instrument will serve as a vehicle in the effort of translating molecular medicine into the clinical settings.