Small Animal MicroCT

描述（由申请人提供）：本提案的长期目标是通过采用小动物MicroCT（Inveon MicroCT）成像技术来提高我们的知识。该仪器具有高分辨率（27微米），最适合加州大学欧文分校（UCI）的小动物研究人员。此外，与现有的高分辨率Inveon MicroPET相结合，它将允许多模态成像，用于研究小动物的生理和生化机制，比UCI更详细。UCI的精神病学和人类行为，放射科学，药理学，生理学和生物物理学，解剖学和神经生物学，神经生物学和行为，生物化学，医学，整形外科，生物医学工程，放射性药物实验室和MicroPET成像设施等部门都参与了使用成像方法来研究正常和异常的生理过程。UCI的研究人员在各种条件下的人类研究中使用成像技术有着悠久的传统，UCI各个中心和部门的大量研究人员都参与了啮齿动物模型的研究。获得高分辨率MicroCT扫描仪将使许多项目的研究人员能够以约27微米的分辨率研究体内和体外啮齿动物模型，并协助转化研究。UCI的研究人员将首次结合高分辨率MicroPET，能够准确评估肿瘤学、心脏病学、骨骼学、神经科学和其他应用中的啮齿动物模型。UCI的成像研究在基础动物研究与临床研究的密切联系方面是独一无二的，如各种项目所示。在动物模型上进行的研究将大大提高我们理解和解释人类研究的能力。新的MicroCT扫描仪将被安置在Inveon MicroPET所在的Medical Sciences I中。本科生，研究生和住院医师在各个部门招收的培训，在各种非侵入性成像方法。教育，培训和经验的程度不同2个月至4年之间为每个学生根据课程和论文工作的水平与成像。MicroCT将成为他们教育和培训的一个组成部分。MicroCT扫描仪将在Jogesh Mukherjee博士的指导下进行，来自五个不同部门（放射科学，医学，药理学，神经生物学和行为学以及生物化学）的团队将提供有效操作和最大限度利用MicroCT所需的行政，科学和技术专业知识。 公共卫生相关性：这是一项关于小动物MicroCT设备的申请。MicroCT将支持加州大学欧文分校开发用于研究各种癌症（乳腺癌、肺癌、前列腺癌和其他癌症，包括骨转移）、糖尿病、骨质疏松症、冠状动脉疾病、神经退行性疾病、神经精神疾病（精神分裂症、抑郁症）、药物滥用和替代医学方法的诊断方法。

DESCRIPTION (provided by applicant): The long-term goal of this proposal is to advance our knowledge by employing imaging techniques using small animal MicroCT (Inveon MicroCT). This instrument has high resolution (27 microns) and will be most suitable for small animal investigators at University of California-Irvine (UCI). Additionally, in association with an existing high resolution Inveon MicroPET it will allow multi-modality imaging for the study of physiology and biochemical mechanisms with greater detail in small animals than has been possible at UCI. Departments of Psychiatry and Human Behavior, Radiological Sciences, Pharmacology, Physiology and Biophysics, Anatomy and Neurobiology, Neurobiology and Behavior, Biological Chemistry, Medicine, Orthopedic Surgery, Biomedical Engineering, Radiopharmaceutical Laboratories and MicroPET Imaging Facility at UCI have all been involved in using imaging methodology to study normal and abnormal physiological processes. Researchers at UCI have a long tradition of using imaging in human studies of various conditions and a large number of researchers at the various centers and Departments in UCI are involved in studying rodent models. The acquisition of a high resolution MicroCT scanner will allow researchers in numerous projects to study in vivo and in vitro rodent models with a resolution of about 27 microns and assist in translational research. For the first time, investigators at UCI in conjunction with the high resolution MicroPET will be able to accurately assess rodent models in oncology, cardiology, osteology, neurosciences and other applications. Imaging research at UCI is unique in terms of the close association of investigators in basic animal research with clinical research as exemplified in the various programs. Studies carried out on the animal models will greatly enhance our ability to understand and interpret human studies. The new MicroCT scanner will be housed in Medical Sciences I where the Inveon MicroPET is housed. Undergraduate, graduate students and residents enrolled in various departments are trained in various non- invasive imaging methods. The degree of education, training and experience vary between 2 months to 4 years for each student based on the level of courses and thesis work related to imaging. The MicroCT will be an integral part of their education and training. The MicroCT scanner will be under the direction of Dr. Jogesh Mukherjee, and a team from five different departments (Radiological Sciences, Medicine, Pharmacology, Neurobiology and Behavior and Biological Chemistry) that will provide administrative, scientific, and technical expertise necessary for the effective operation and maximal utilization of the MicroCT will be in place. PUBLIC HEALTH RELEVANCE: This is a request for a small animal MicroCT equipment. Development of diagnostic methods for the study of various cancers (breast, lung, prostate and others, including bone metastasis), diabetes, osteoporosis, coronary artery disease, neurodegenerative disorders, neuropsychiatric illness (schizophrenia, depression), substance abuse and alternative medicine approaches at University of California-Irvine will be supported by MicroCT.