Small Animal PET (microPET)

小动物 PET (microPET)

• 批准号: 7214391
• 负责人: Jogeshwar Mukherjee
• 金额: $ 50万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7214391
• 关键词: Small; Animal; PET; microPET

DESCRIPTION (provided by applicant): The long-term goal of this proposal is to advance our knowledge by employing imaging techniques using a small animal positron emission tomograph (microPET Focus 120). This instrument has high resolution and high sensitivity and will therefore allow the study of biochemical mechanisms with greater detail in small animals than has been possible before. The Brain Imaging Center (BIC), Center for Functional Onco-Imaging (CFOI), Departments of Pharmacology, Anatomy and Neurobiology, Neurobiology and Behavior, Biological Chemistry, Medicine, Transdisciplinary Tobacco Use Research Center (TTURC), Radiopharmaceutical Laboratories all at University of California-Irvine (UCI) have been involved in using imaging methodology to study normal and abnormal physiological processess. Researchers at UCI have a long tradition of using PET in human studies of various conditions. A large number of researchers at the various centers and Departments in UCI are involved in studying rodent models. The acquisition of a microPET scanner will allow researchers in numerous projects to study in vivo brain function with a resolution of about 1.5 mm or less. For the first time, investigators at UCI will be able to accurately assess functional activity in small regions in the brain noninvasively. Imaging research at UCI is unique in terms of the close association of investigators in basic animal research with clinical research as exemplified in the various programs. Studies carried out on the animal models will greatly enhance our ability to understand and interpret human studies. The new microPET scanner will be housed in Irvine Hall, where the BIC and Center for CFOI are located and houses the human PET scanners, the MC-17 medical cyclotron, radiopharmaceutical laboratories, MR scanners, Optical Imaging Lab and rodent animal facility. The microPET scanner will be under the direction of Dr. Jogesh Mukherjee, and a team from five different departments (Radiology, Medicine, Pharmacology, Neurobiology and Behavior and Biological Chemistry) that will provide administrative, scientific, and technical expertise necessary for the effective operation and maximal utilization of the microPET will be in place.

描述（由申请人提供）：本提案的长期目标是通过使用小型动物正电子发射断层扫描仪（microPET Focus 120）的成像技术来提高我们的知识。该仪器具有高分辨率和高灵敏度，因此可以比以前更详细地研究小动物的生化机制。加州大学欧文分校（UCI）的脑成像中心（BIC）、功能性肿瘤成像中心（CFOI）、药理学、解剖学和神经生物学、神经生物学和行为学、生物化学、医学系、跨学科烟草使用研究中心（TTURC）、放射性药物实验室都参与了使用成像方法研究正常和异常生理过程。UCI的研究人员在各种条件下的人体研究中使用PET有着悠久的传统。UCI各中心和部门的大量研究人员都参与了啮齿动物模型的研究。微型pet扫描仪的获得将使许多项目的研究人员能够以大约1.5毫米或更小的分辨率研究体内大脑功能。UCI的研究人员将首次能够无创地准确评估大脑小区域的功能活动。UCI的影像研究在基础动物研究与临床研究的密切联系方面是独一无二的，这在各种项目中得到了例证。在动物模型上进行的研究将大大提高我们理解和解释人类研究的能力。新的微型PET扫描仪将被安置在Irvine大厅，那里是BIC和CFOI中心的所在地，并容纳人类PET扫描仪，MC-17医疗回旋加速器，放射性药物实验室，MR扫描仪，光学成像实验室和啮齿动物设施。微型pet扫描仪将由Jogesh Mukherjee博士指导，来自五个不同部门（放射学、医学、药理学、神经生物学、行为和生物化学）的团队将为有效操作和最大限度地利用微型pet提供必要的管理、科学和技术专业知识。

项目成果

Adrenergic pathway activation enhances brown adipose tissue metabolism: a [¹⁸F]FDG PET/CT study in mice.

• DOI: 10.1016/j.nucmedbio.2013.08.009
• 发表时间: 2014-01
• 期刊: Nuclear medicine and biology
• 影响因子: 3.1
• 作者: Mirbolooki MR;Upadhyay SK;Constantinescu CC;Pan ML;Mukherjee J
• 通讯作者: Mukherjee J

Performance evaluation of an Inveon PET preclinical scanner.

• DOI: 10.1088/0031-9155/54/9/020
• 发表时间: 2009-05-07
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Constantinescu CC;Mukherjee J
• 通讯作者: Mukherjee J

Evaluation of serotonin 5-HT(1A) receptors in rodent models using [¹⁸F]mefway PET.

• DOI: 10.1002/syn.21665
• 发表时间: 2013-09
• 期刊: SYNAPSE
• 影响因子: 2.3
• 作者: Saigal, Neil;Bajwa, Alisha K.;Faheem, Sara S.;Coleman, Robert A.;Pandey, Suresh K.;Constantinescu, Cristian C.;Fong, Vanessa;Mukherjee, Jogeshwar
• 通讯作者: Mukherjee, Jogeshwar

Multimodality Imaging Probe for Positron Emission Tomography and Fluorescence Imaging Studies

• DOI: 10.2310/7290.2014.00005
• 发表时间: 2014-05
• 期刊: Molecular Imaging
• 影响因子: 2.8
• 作者: S. Pandey;Jasmeet Kaur;Balu Easwaramoorthy;Ankur J Shah;R. Coleman;J. Mukherjee

Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation.

• DOI: 10.1186/2191-219x-1-30
• 发表时间: 2011-12-01
• 期刊: EJNMMI research
• 影响因子: 3.2
• 作者: Mirbolooki MR;Constantinescu CC;Pan ML;Mukherjee J
• 通讯作者: Mukherjee J