Small Animal PET (microPET)

描述（由申请人提供）：本提案的长期目标是通过使用小动物正电子发射断层扫描仪（microPET Focus 120）的成像技术来推进我们的知识。该仪器具有高分辨率和高灵敏度，因此可以比以前更详细地研究小动物的生化机制。脑成像中心（BIC），功能肿瘤成像中心（CFOI），药理学，解剖学和神经生物学，神经生物学和行为学，生物化学，医学，跨学科烟草使用研究中心（TTURC），放射性药物实验室都在加州大学欧文分校（UCI）参与使用成像方法来研究正常和异常的生理过程。UCI的研究人员在各种条件下的人体研究中使用PET有着悠久的传统。UCI各中心和部门的大量研究人员参与了啮齿动物模型的研究。microPET扫描仪的获得将使许多项目的研究人员能够以约1.5 mm或更小的分辨率研究体内脑功能。UCI的研究人员将首次能够无创地准确评估大脑小区域的功能活动。UCI的成像研究在基础动物研究与临床研究的密切联系方面是独一无二的，如各种项目所示。在动物模型上进行的研究将大大提高我们理解和解释人类研究的能力。新的microPET扫描仪将被安置在Irvine Hall，BIC和CFOI中心位于该中心，并容纳人体PET扫描仪，MC-17医用回旋加速器，放射性药物实验室，MR扫描仪，光学成像实验室和啮齿动物设施。microPET扫描仪将在Jogesh Mukherjee博士的指导下进行，来自五个不同部门（放射学，医学，药理学，神经生物学和行为学以及生物化学）的团队将提供有效操作和最大限度利用microPET所需的行政，科学和技术专业知识。

DESCRIPTION (provided by applicant): The long-term goal of this proposal is to advance our knowledge by employing imaging techniques using a small animal positron emission tomograph (microPET Focus 120). This instrument has high resolution and high sensitivity and will therefore allow the study of biochemical mechanisms with greater detail in small animals than has been possible before. The Brain Imaging Center (BIC), Center for Functional Onco-Imaging (CFOI), Departments of Pharmacology, Anatomy and Neurobiology, Neurobiology and Behavior, Biological Chemistry, Medicine, Transdisciplinary Tobacco Use Research Center (TTURC), Radiopharmaceutical Laboratories all at University of California-Irvine (UCI) have been involved in using imaging methodology to study normal and abnormal physiological processess. Researchers at UCI have a long tradition of using PET in human studies of various conditions. A large number of researchers at the various centers and Departments in UCI are involved in studying rodent models. The acquisition of a microPET scanner will allow researchers in numerous projects to study in vivo brain function with a resolution of about 1.5 mm or less. For the first time, investigators at UCI will be able to accurately assess functional activity in small regions in the brain noninvasively. Imaging research at UCI is unique in terms of the close association of investigators in basic animal research with clinical research as exemplified in the various programs. Studies carried out on the animal models will greatly enhance our ability to understand and interpret human studies. The new microPET scanner will be housed in Irvine Hall, where the BIC and Center for CFOI are located and houses the human PET scanners, the MC-17 medical cyclotron, radiopharmaceutical laboratories, MR scanners, Optical Imaging Lab and rodent animal facility. The microPET scanner will be under the direction of Dr. Jogesh Mukherjee, and a team from five different departments (Radiology, Medicine, Pharmacology, Neurobiology and Behavior and Biological Chemistry) that will provide administrative, scientific, and technical expertise necessary for the effective operation and maximal utilization of the microPET will be in place.