Oncogenic fusions in melanoma

在黑色素瘤中，我们假设存在一系列尚未确定的基因融合，它们提供了促进肿瘤生长的致癌刺激信号，这些新型融合产品是设计治疗黑色素瘤新疗法的极佳靶点。这项研究的目的是鉴定黑色素瘤中的致癌融合，评估其中哪些是复发的，并证明由此产生的融合蛋白为肿瘤细胞提供了选择性的生长和-或生存优势。

In melanoma we hypothesise there is a series of as yet unidentified gene fusions which provide oncogenic stimulatory signals that promote tumour growth and that these novel fusion products are excellent targets for the design of new therapies to treat melanoma. The aims of this study are to identify oncogenic fusions in melanoma, to assess which of these are recurrent, and to demonstrate that the resulting fusion proteins provide a selective growth and-or survival advantage to the tumour cell.