PIKOBODIES: Made-to-order plant disease resistance genes using receptor-nanobody fusions

PIKOBODIES：利用受体-纳米抗体融合定制植物抗病基因

• 批准号: EP/Y032187/1
• 负责人: Sophien Kamoun
• 金额: $ 269.79万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY032187%2F1
• 关键词: PIKOBODIES; Made; order; plant; disease

PIKOBODIES is a daring project that aims to revolutionize the way we protect plants from diseases. Unlike animals, plants do not have an adaptive immune system, instead, they rely on innate receptors to detect and fend off harmful invaders. Until now, our efforts to enhance this natural defense system have had limited success, with new types of diseases often managing to overcome our engineered solutions.However, with PIKOBODIES, we are set to change the game. We've discovered that we can use these innate plant receptors and combine them with VHH nanobodies - these are tiny but powerful parts of the antibodies found in animals like camels. This innovative fusion can activate the plant's defense mechanisms when specific disease-causing organisms are present, and can effectively make the plant resistant to the disease.What's truly exciting about this project is that nanobodies can be designed to recognize almost any kind of molecule. This means that we can potentially engineer plant defenses against a broad spectrum of diseases, pests, and any other threats that manage to get inside plant cells.Through this project, we'll delve deeper into understanding how Pikobodies work, and how we can improve their design and deployment. We're essentially aiming to give plants a sort of 'vaccination' system, which can adapt to different threats much like the immune systems of mammals.By pioneering this new technology, PIKOBODIES could offer an effective and versatile way to safeguard our precious plant life from disease. This isn't just a step forward for bioengineering - it's a giant leap for protecting our global food supply.

PIKOBOOTH是一个大胆的项目，旨在彻底改变我们保护植物免受疾病侵害的方式。与动物不同，植物没有适应性免疫系统，而是依靠先天受体来检测和抵御有害的入侵者。到目前为止，我们增强这种天然防御系统的努力取得了有限的成功，新类型的疾病往往能够克服我们的工程解决方案。然而，PIKOBO，我们将改变游戏。我们已经发现，我们可以利用这些天然的植物受体，并将它们与VHH纳米抗体联合收割机结合--这些是在骆驼等动物中发现的抗体的微小但强大的部分。这种创新的融合可以激活植物的防御机制，当特定的致病生物存在时，可以有效地使植物抵抗疾病。这个项目真正令人兴奋的是，纳米抗体可以被设计为识别几乎任何种类的分子。这意味着我们有可能设计植物防御系统来抵御各种疾病、害虫和任何其他设法进入植物细胞的威胁。通过这个项目，我们将深入了解Pikobodies的工作原理，以及我们如何改进它们的设计和部署。我们的目标是为植物提供一种“疫苗接种”系统，它可以像哺乳动物的免疫系统一样适应不同的威胁。通过开创这项新技术，PIKOBOOTH可以提供一种有效和多功能的方法来保护我们宝贵的植物生命免受疾病的侵害。这不仅仅是生物工程向前迈出的一步，也是保护全球粮食供应的一大步。