Nurse Managed Cognitive Behavioral Therapy for Insomnia in People with COPD

描述(由申请者提供)：这个指导研究科学家发展奖(K01)的目的是为申请者提供必要的技能和知识，以开发和测试认知行为疗法干预措施，以促进慢性阻塞性肺疾病(COPD)患者的症状管理和最佳功能。具体的职业目标是：(1)学习与睡眠相关的生理学、失眠和与睡眠相关的行为理论；(2)了解与睡眠相关的基本监测程序、诊断测试和生物行为结果，包括多导睡眠图、动作图和睡眠记录；以及(3)发展失眠认知行为疗法的专业知识，并对COPD患者的认知行为疗法进行初步研究。提出了一项分两个阶段的研究。在研究的第一阶段，对失眠的认知行为疗法干预将在一小部分(n=5)中重度COPD和失眠患者中实施。干预措施将进行试点测试，以确定可行性和可接受性，并将根据需要对干预措施进行完善。在研究的第二阶段，将进行两组随机对照研究(n=20)，以测试失眠干预的认知行为疗法对睡眠质量、疲劳、情绪和功能表现的影响。据推测，与接受健康计划的COPD患者相比，接受认知行为疗法治疗失眠的COPD患者将在睡眠质量、疲劳、情绪和功能表现方面表现出显著改善。这项研究将产生关于有效干预的有价值的信息，旨在缓解睡眠质量差、疲劳和执行有价值的日常活动的能力下降等问题。这些信息将被用来增加长期成功结果的可能性，例如为慢性阻塞性肺病患者保持社会中生产性角色的能力。

DESCRIPTION (provided by applicant): The aim of this Mentored Research Scientist Development Award (K01) is to provide the applicant with the skills and knowledge necessary to develop and test cognitive behavioral therapy interventions to promote symptom management and optimal function in people with chronic obstructive pulmonary disease (COPD). Specific career objectives are to: (1) study sleep-related physiology, insomnia and sleep-related behavioral theories; (2) gain an understanding of basic sleep-related monitoring procedures, diagnostic tests and biobehavioral outcomes, including polysomnography, actigraphy and sleep logs; and (3) develop expertise in cognitive behavioral therapy for insomnia and conduct a preliminary study of cognitive behavioral therapy in people with COPD. A two-phase research study is proposed. In Phase 1 of the study, the cognitive behavioral therapy intervention for insomnia will be implemented in a small (n = 5) group of people with moderate to severe COPD and insomnia. The intervention will be pilot-tested to determine feasibility and acceptability, and the intervention will be refined as needed. In Phase 2 of the study, a two-group randomized controlled study (n = 20) will be conducted to test the effects of the cognitive behavioral therapy for insomnia intervention on sleep quality, fatigue, mood and functional performance. It is hypothesized that people with COPD receiving cognitive behavioral therapy for insomnia will demonstrate significant improvements in sleep quality, fatigue, mood and functional performance as compared to people with COPD who receive a wellness program. This research will yield valuable information regarding effective interventions aimed at mitigating problems such as poor sleep quality, fatigue and reduced ability to perform valued daily activities. This information will be used to increase the likelihood of long-term successful outcomes such as the ability to maintain productive roles in society for people with COPD.