Aerobic and Resistance Exercise for Cancer-Related Fatigue During Radiation

简介（由申请人提供）：概述：Karen Mustian博士，一位运动心理学家，正在申请导师职业发展奖，以扩大她的研究技能，并成为癌症控制方面的独立研究者。她的目标是促进对运动干预的理解，以减少癌症治疗的副作用，特别是癌症相关疲劳（CRF）；患者中最普遍的副作用。拟议的项目在理论上以CRF研究和de/conditioning理论为指导，假设体力活动减少会导致肌肉质量和力量的损失，而阻力运动可以改善这两者。职业发展规划：Mustian博士之前在运动心理学、行为医学和癌症控制方面的研究和培训为他提供了一个坚实的基础，他将通过在研究技能、癌症控制、综合系统生物学和生理学以及健康技术方面的具体可测量学习的教育计划来加强这一基础。她的主要导师加里·莫罗博士是癌症控制研究和培训领域的领导者，已有30年的历史。他将在癌症和副作用管理以及随机临床试验设计和分析方面贡献专业知识。Mustian博士的共同导师也有培训研究人员的特殊经验。医学博士Alice Pentland将在癌症生物学和跨学科研究方面贡献专业知识，以创造用于定量评估的健康技术。医学博士安妮·麦克蒂尔南（Anne McTiernan）将贡献运动和癌症方面的专业知识。顾问委员会成员也将为Mustian博士的职业发展贡献他们独特的专业知识。研究计划：拟议的研究项目是一项随机临床试验，旨在扩大可行性研究的积极结果，并检查114名接受放射治疗的乳腺癌患者家中步行和渐进式阻力运动计划对CRF的影响。次要研究目标是为潜在的CRF病因提供初步信息，包括骨骼肌质量损失、力量变化和与蛋白酶体泛素途径相关的炎症反应失调，以及使用活动记录运动数据作为CRF的独立标志物。这些结果将有助于阐明运动对CRF的公共健康影响，协助为CRF量身定制运动干预措施，为未来的R01研究提供CRF潜在病因和独立标志物的试点数据，并使Mustian博士成功过渡到癌症控制科学的独立研究者和领导者。

DESCRIPTION (provided by applicant): Overview: Karen Mustian, Ph.D., an exercise psychologist, is applying for a mentored career development award to expand her research skills and become an independent investigator in cancer control. Her goal is to contribute to the understanding of exercise interventions for reducing the side effects of cancer treatments, specifically, cancer-related fatigue (CRF); the most prevalent side effect in patients. The proposed project is theoretically guided by CRF research and de/conditioning theory positing reduced physical activity results in loss of muscle mass and strength, and resistance exercise improves both. Career Development Plan: Dr. Mustian's previous research and training in exercise psychology, behavioral medicine, and cancer control provide a strong foundation that will be enhanced by the educational plan of specific measurable learning in research skills, cancer control, integrative systems biology and physiology, and health technology. Her primary mentor, Gary Morrow, Ph.D., has been a leader in cancer control research, and training for 30 years. He will contribute expertise in cancer and side effect management and in randomized clinical trial design and analyses. Dr. Mustian's co-mentors also have exceptional experience training researchers. Alice Pentland, M.D. will contribute expertise in cancer biology, and interdisciplinary research to create health technology for quantitative assessment. Anne McTiernan, M.D., Ph.D. will contribute expertise in exercise and cancer. Advisory board members will also contribute their unique expertise to Dr. Mustian's career development. Research Plan: The proposed research project is a randomized clinical trial to expand the positive findings of a feasibility study and examine the influence of a home-based walking and progressive resistance exercise program on CRF in 114 breast cancer patients undergoing radiation. Secondary research goals are to provide pilot information on potential CRF etiological factors, including skeletal muscle mass loss, strength changes, and dysregulation of inflammatory responses associated with the proteasome ubiquitin pathway, and on the use of actigraphy motion data as an independent marker of CRF. These results will help elucidate the public health impact of exercise on CRF, assist in tailoring exercise interventions for CRF, provide pilot data on potential etiological factors and independent markers of CRF for a future R01 study, and position Dr. Mustian to successfully transition to an independent investigator and leader in cancer control science.