Training Grant in Clinical Pharmacology

描述（由申请人提供）：本提案代表了对NIH申办的马约诊所-马约诊所医学院-马约医学院临床药理学研究金培训项目的持续资助请求。这种研究培训经验被整合到一个广泛的课程中，使学员接触到临床药理学基础科学的关键方面-所有这些都在支持性的指导环境中。临床药理学是一个“桥梁学科”，致力于研究人类和药物之间的相互作用。在生物医学科学正在进行的“革命”的背景下，一场有望改变医疗实践的革命，临床药理学是分子药理学，基因组学，蛋白质组学，生物信息学和合理治疗学学科的融合-最终目标是科学的“个性化”药物治疗。因此，临床药理学旨在提高我们对药物反应的分子基础的理解，并将这些信息应用于翻译界面，以便能够根据潜在的疾病过程和每个患者的独特特征定制药物治疗。然而，我们利用这一独特机会的能力将要求我们在“新生物学”提供的基础上培养新一代的临床药理学家。像马约诊所这样的大型、综合性、综合性学术医疗中心是培养新一代临床药理学家的理想场所。马约能够做到这一点，是因为它在整合基础和临床医学研究方面的悠久历史，是因为它长期致力于临床药理学学科，是因为马约临床药理学培训计划在成功招募和培训医生科学家方面拥有数十年的经验，也是因为马约在转化科学方面的历史重点。马约临床药理学研究员培训计划将继续强调强大的实验室研究培训、系统的临床科学接触和结构化的指导-目标是使每位研究员成为临床药理学的未来领导者。

DESCRIPTION (provided by applicant): This proposal represents a request for continued funding of the NIH-sponsored Clinical Pharmacology Fellowship Training Program at the Mayo Clinic-Mayo Clinic College of Medicine-Mayo Medical School. This research training experience is integrated within a broad curriculum that exposes Trainees to critical aspects of the science underlying Clinical Pharmacology ~ all within a supportive, mentoring environment. Clinical Pharmacology represents a "bridge discipline" that is devoted to the study of the interaction between humans and drugs. Within the context of the ongoing" revolution" that is occurring in biomedical science, a revolution that promises to transform medical practice, Clinical Pharmacology lies at the confluence of the disciplines of molecular pharmacology, genomics, proteomics, bioinformatics and rational therapeutics - with an ultimate goal of scientifically "individualized" drug therapy. Therefore, Clinical Pharmacology seeks to enhance our understanding of the molecular basis for drug response and to apply that information at the translational interface to make it possible to tailor drug therapy to both the underlying disease process and the unique characteristics of each individual patient. However, our ability to take advantage of this unique opportunity will require that we train a new generation of Clinical Pharmacologists in science that is based on a foundation provided by the "new biology". Large, comprehensive, integrated academic medical centers like the Mayo Clinic are ideally positioned to train this new generation of Clinical Pharmacologists. Mayo is able to do that because of its long history of integrating basic and clinical medical research, because of a long tradition of contributing to the discipline of Clinical Pharmacology, because the Mayo Clinical Pharmacology Training Program has had decades of experience in successfully recruiting and training physician scientists and because of an historical focus at Mayo on translational science. The Mayo Clinical Pharmacology Fellowship Training Program will continue to emphasize strong laboratory-based research training, systematic exposure to clinical science, and a structured mentorship - with the goal of preparing each Fellow to become a future leader in Clinical Pharmacology.