Human Adoptive Transfer Core

这个核心的目的是使用异种移植小鼠模型来为该计划项目中提出的实验提供体内读数。具体地说，该模型将用于以下目的： 1.优化T细胞(Treg)的增殖和功能以抑制同种异体反应。 2.对人类胸腺细胞前体细胞(Tprog)将加速免疫缺陷小鼠的胸腺生成和外周血T细胞反应的假说进行研究。 3.优化自然杀伤(NK)细胞的增殖和功能，用于白血病的治疗。 这些数据将反过来为未来临床试验的设计提供信息。 核心领导者将提供干细胞生物学、基因操作、小鼠模型和临床造血细胞移植的宝贵知识，所有这些都与这一应用相关。核心D的独特之处在于，它允许三名首席研究人员中的两名(他们无法获得临床前小鼠模型；项目1和3)拥有关键的共享资源，以加强他们的科学计划。

The aim of this core is to use a xenotransplantation murine model to provide in vivo readouts for experiments proposed in this program project. Specifically, this model will be used for the following purposes: 1. To optimize proliferation and function of T regulatory cells (Treg) for suppression of alloreactive responses. 2. To perform studies testing the hypothesis that human thymocyte progenitor cells (Tprog) will accelerate human thymopoiesis and peripheral blood T cell responses in immunodeficient mice. 3. To optimize proliferation and function of natural killer (NK) cells for leukemia therapy. These data will in turn inform the design of future clinical trials. The core leader will provide valuable knowledge of the stem cell biology, gene manipulations, murine models, and clinical hematopoietic cell transplantation, all relevant to this application. Core D is unique in its capability to allow two of the three Principal Investigators (who do not have access to preclinical murine models; Project 1 and 3) with a critical shared resource to enhance their scientific program.