ACTIVITY #3 - ENHANCEMENT OF NEUROGENETICS RESEARCH AT THE INST OF NEUROBIOLOGY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 波多黎各大学医学科学校区的一个主要长期目标是扩大和改善分子神经科学的环境。 为了帮助实现这一目标，该项目将在神经生物学研究所建立一个神经遗传学核心设施（具体目标1）。这一设施将用于提高现有教师的研究能力，并将作为研究所进一步发展的资源。这一目标的一个关键特征将是招募一名神经遗传学家来领导该机构。资金将用于改造实验室空间，获得主要仪器，支持神经遗传学或神经基因组学领域的合作，以及招募过程。它们还将用于发展神经生物学研究所和外部研究人员之间的合作研究团队。 根据上一个RCMI倡议建立的分子神经生物学核心设施的运作也将继续（具体目标2）。 该设施毗邻被提议用于容纳神经遗传学核心的空间。 参与本提案的各方广泛使用了这一工具，并将其视为研究的重要资产。 该研究所的所有分子生物学都集中在这个设施上，预计它也将成为神经遗传学研究的重要资源。 此外，还将改善研究所与波多黎各以外的研究团体之间的交流（具体目标3）。这将通过改善互联网连接、视频会议能力以及实施支持与外部科学家合作的机制来实现。总的来说，这些变化将为神经生物学研究所增加强大的新研究和培训能力，并增强现有能力。 它们还将有助于在当前的研究和公共卫生之间建立更好的联系。这些变化是必要的，以满足不断变化的环境神经科学研究的挑战。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major long-term objective of the University of Puerto Rico Medical Sciences Campus is to expand and improve the environment for molecular neuroscience. To help meet that goal, this project will establish a Neurogenetics Core Facility at the Institute of Neurobiology (Specific Aim 1). This facility will be used to enhance the research capabilities of the present faculty and will serve as a resource for the further development of the Institute. A key feature of this aim will be to recruit a neurogeneticist to head the facility. Funds will be used to remodel lab space, obtain major instrumentation, support collaborations in the areas of neurogenetics or neurogenomics, and for the recruitment process. They will also be used to develop collaborative research teams between the Institute of Neurobiology and outside researchers. The operation of the Molecular Neurobiology Core Facility, established under the last RCMI initiative, will also be continued (Specific Aim 2). This facility is adjacent to the space that is being proposed to house the Neurogenetics Core. It has been used extensively by the participants in this proposal and is considered a vital asset for their research. All molecular biology at the Institute centers on this facility, and it is anticipated that it will also be an essential resource for investigation in neurogenetics. In addition, improvements will be made in communications between the Institute and research groups outside of Puerto Rico (Specific Aim 3). This will be accomplished by improving the internet connections, video conferencing capabilities and by implementing a mechanism to support collaborations with outside scientists. Taken together, these changes will add powerful new research and training capabilities to the Institute of Neurobiology, as well as enhance existing capabilities. They will also help create better links between current research and public health. These changes are required to meet the challenges of an evolving environment for Neuroscience research.