BIOTECHNOGY: PATHWAYS TO DISEASE PREVENTION AND THERAPY (BPDPT)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 更改： 由于BPDPT活动负责人Ronald Thomas博士的英年早逝和BPDPT的教务顾问Ann Heiman博士的退休，BPDPT的组织结构发生了变化。基础药学教授卡尔·古德曼博士是BPDPT的核心负责人。他是一位非常有经验的研究员，具有出色的管理技能，曾担任BPDPT核心活动负责人。BPDPT生物技术核心已经重组了研究结构，配备了适当的人员： 基因组学协调员：卡尔·古德曼博士 蛋白质组学协调员：纳扎里乌斯·拉曼戈博士和塞琳娜·达林-里德博士 流式细胞术协调员：Ebenzer Oriaku博士和Selina Darling-Reed博士 DNA损伤和修复协调员：巴拉克·阿博约博士。 学院研究科学家：Selina Darling-Reed博士 副研究员：Ramesh Badisa博士和Equar Taka博士，并将在制药科学中提供流式细胞术和蛋白质组学应用方面的服务。 摘要 生物技术：疾病预防和治疗的途径(BPDPT)是先前资助的分子生物学研究活动的扩展。其持续的使命是为大学生物医学研究人员提供当代分子生物学技术和技术专长。这将加强佛罗里达农工大学的研究基础设施。这项工作的长期目标是建立信息和技术资源，以增加研究人员的分子生物学专业知识，持续的研究人员合作，并培育新的生物医学研究合作项目。BPDPT的开发还将增加佛罗里达农工大学新的教师招聘机会。为了实现这些目标，已经确定了以下具体目标：1)建立分子生物学研究所需的设备基础设施；2)为生物医学研究人员建立一个大学范围内的合作环境；3)促进教师接受分子生物学培训的途径；以及4)增加参与分子生物学研究的研究人员的数量。目前已建立了实时荧光定量聚合酶链式反应、蛋白印迹分析、凝胶电泳法分析蛋白质、DNA、RNA、彗星试验、流式细胞术等传统分子生物学技术。在拟议的活动中，我们计划扩大分子生物学专业知识，以包括蛋白质组学和基因组学。最终，我们计划将分子生物学研究活动扩展到一个功能齐全、自给自足的核心设施。总体而言，BPDPT将有助于建立有益的资源，从而增加研究人员的分子生物学专业知识，持续的研究人员合作，并促进新的生物医学研究合作项目，并加强佛罗里达农工大学的研究基础设施。由NIH/NCRR/RCMI G12RR03020支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Changes: Due to the untimely death of Dr. Ronald Thomas (BPDPT Activity Leader) and the retirement of Dr. Ann Heiman (Faculty Advisor for Flow Cytometry Facility), the BPDPT has experienced a change in its organization. Dr. Carl Goodman, Professor, Basic Pharmaceutical Sciences, serves as the BPDPT Core Leader. He is a very experienced researcher with outstanding managerial skills, has assumed the responsibilities as Activity Leader for the BPDPT Core. The BPDPT Biotechnology Core has reorganized the research structure with the appropriate personnel: Genomics Coordinator: Dr. Carl Goodman Proteomics Coordinator: Dr. Nazarius Lamango & Dr. Selina Darling-Reed Flow Cytometry Coordinator: Dr. Ebenezer Oriaku & Dr. Selina Darling-Reed DNA Damage and Repair Coordinator: Dr. Barack Abonyo. Faculty Research Scientist: Dr. Selina Darling-Reed Research Associates: Drs. Ramesh Badisa and Equar Taka and will provide the service in Flow Cytometry and Proteomics application in Pharmaceutical Sciences. ABSTRACT The Biotechnology: Pathways to Disease Prevention and Therapy (BPDPT) is an expansion of the previously funded molecular biology research activity. Its' continuing mission is to provide the university biomedical research investigators with contemporary molecular biology technology and technical expertise. This will strengthen the research infrastructure at Florida A & M University. The long-term goal of this effort is to establish Informational and technical resources that will result in increased molecular biology expertise of the research faculty, continual investigator collaborations, and foster new biomedical research collaborative ventures. Development of the BPDPT will also increase new faculty recruitment opportunities at Florida A & M University. To complete these goals the following specific aims have been identified: 1) Establish the equipment infrastructure needed for molecular biology research; 2) Develop a University wide collaborative environment for biomedical research investigators; 3) Facilitate avenues by which Faculty can receive molecular biology training; and 4) Increase the number of investigators involved in molecular biology research. Currently we have established traditional molecular biology technology including real-time PCR; western blot analysis; protein, DNA, & RNA analysis via gel electrophoresis; DNA damage analysis via the COMET assay, and flow cytometry. In the proposed activity we plan to expand the molecular biology expertise to include proteomics and genomics. Ultimately, we plan to expand the molecular biology research activity to a full functioning self-sustaining core facility. Overall, the BPDPT will serve to establish beneficial resources that will result in increased molecular biology expertise of the research Faculty, continual investigator collaborations, and foster new biomedical research collaborative ventures and strengthens the research infrastructure at Florida A & M University. Supported by NIH/NCRR/RCMI G12RR03020.