A Resource for Genetic Epidemiology Research in Adult Health and Aging

描述（由申请人提供）：这个“大机遇”项目的目标是创建一个独特而全面的基于人群的资源，用于研究常见的与年龄有关的疾病及其治疗的遗传和环境基础，以及影响健康老龄化和长寿的因素。拟议的资源将汇集到一个广泛可访问的数据库中，这是一个非常丰富的数据集，涉及10万名基因、环境和健康研究计划（RPGEH）的参与者，该研究计划基于北加州凯撒永久医疗保健计划（KPNC）。RPGEH包括KPNC的综合、纵向电子病历数据；一份包含人口统计、行为和其他危险因素数据的参与者问卷；地理信息系统（GIS）数据库，将环境暴露（如空气和水质）和社区特征映射到参与者的居住历史；并使用Oragene试剂盒获取所有参与者的唾液样本。10万名完成RPGEH的参与者普遍同意将其DNA和其他数据用于研究遗传和环境对健康和疾病的影响。调查对象的平均年龄为65岁，所有主要民族都有很好的代表性。在本提案中，我们特别申请资金，使用一种新的Affymetrix GeneTitan基因分型系统，为资源添加有价值的70万个snp全基因组关联数据和端粒长度测量，以便对影响成人发病疾病风险及其治疗和健康衰老的遗传和环境因素进行全面研究。snp的选择将是定制的，以方便检测新的关联，并跟踪以前确定的关联。KPNC维护的电子临床记录具有纵向性质，这意味着需要分析的表型数据可用于解决长期的健康和疾病问题。我们预计，这一资源将满足国内外大量研究人员的需求，以调查有关老龄化的复杂问题，无论是短期还是未来几年。

DESCRIPTION (provided by applicant): The goal of this "Grand Opportunities" project is to create a unique and comprehensive population-based resource for research into the genetic and environmental basis of common age-related diseases and their treatment, and factors influencing healthy aging and longevity. The proposed resource will bring together into a broadly accessible database, an extraordinarily rich set of data on 100,000 participants in the Research Program on Genes, Environment and Health (RPGEH), based in the Kaiser Permanente Medical Care Plan in Northern California (KPNC). The RPGEH includes data from the comprehensive, longitudinal electronic medical records of KPNC; a participant questionnaire with demographic, behavioral, and other risk factor data; a geographic information system (GIS) database that maps environmental exposures (e.g., air and water quality) and neighborhood characteristics to participants' residential histories; and saliva samples obtained from all participants using Oragene kits. The 100,000 completed participants in RPGEH have broadly consented to have their DNA and other data used to conduct studies of genetic and environmental influences on health and disease. The average age of the subjects is 65 years, with good representation of all the major ethnic groups. In this proposal, we are specifically requesting funds to add valuable genome-wide association data for 700,000 SNPs and measures of telomere length to the resource using a novel Affymetrix GeneTitan genotyping system, to enable comprehensive studies of genetic and environmental factors that influence the risk of adult-onset diseases and their treatment, and healthy aging. The selection of SNPs will be customized to facilitate the detection of new associations and to follow up previously identified associations. The longitudinal nature of the electronic clinical records maintained by KPNC means that the phenotype data subject to analysis can be used to address questions of health and disease over time. We anticipate that this resource will serve the needs of a vast array of researchers both nationally and internationally to investigate complex questions regarding aging, both for the short term and for years to come. PUBLIC HEALTH RELEVANCE: The goal of this "Grand Opportunities" project is to create a unique and comprehensive population-based resource for research into the genetic and environmental basis of common age-related diseases and their treatment, and factors influencing healthy aging and longevity. The proposed resource will bring together into a broadly accessible database, an extraordinarily rich set of data on 100,000 participants. The proposed project will add genetic data on 700,000 SNPs and data on telomere length to data from comprehensive electronic health records; a participant questionnaire with demographic, behavioral, and other risk factor data; a geographic information system (GIS) database that maps environmental exposures to participants' residential histories.