Bioethics Research Infrastructure Initiative

项目摘要/摘要：马里兰大学巴尔的摩分校申请通过“GO”拨款RFA-OD-09-004，在NCMHD ARRA科学优先领域“生物伦理研究基础设施计划”下建立一个生物伦理中心。该生物伦理中心的项目和研究基于一个经过测试和验证的模型，该模型旨在提高农村和城市癌症患者在临床试验和研究中的可用性/参与度，从而获得了美国国土卫生和公众服务部国家最佳实践奖。该模型结合了具体的临床试验累积和障碍研究，针对公众、患者、卫生专业人员（即医生和政策）的教育和培训，这将解决和解决在马里兰州和美国的试验中招募不同社区的障碍。我们在实现临床试验多样性方面所取得的成功包括：癌症中心试验中非裔美国人的累积率为40%，癌症试验（治疗、预防和控制）中非裔美国人的农村累积率为25%，试验可用性增加20倍，农村癌症患者累积率在5年内增加40倍。该中心将支持生物伦理学的综合方法，临床试验参与和研究参与的多样性。通过这种方法和目标，我们将支持国家研究企业在整个连续体中的加速发展。与ARRA和GO资助目标的相关性：中心的目标和项目与ARRA GO资助的意图一致，包括：1。创造就业机会，促进经济投资；2. 为当地服务不足的社区提供经济投资；3. 促进社区能力增强/参与国家研究事业，从而促进加速科学、公共卫生和医学方面的进展；4. 加强社区能力，防止裁员，并在正在进行的经济中建立地方领导；5. 是突破性、创新性、高影响力和跨领域的研究，可以随时部署，并将改善和加速生物医学研究；和6。包括创造性的方法，以克服障碍的基础，转化，或临床研究。中心目标和目的：本中心的目标是最大限度地提高临床试验参与者的多样性。目标1：建立一个国家认可的生物伦理中心，致力于促进少数民族和农村人口更多地参与临床试验；目标2：扩大、进一步发展和实施综合方法，以加强在包括临床试验在内的研究中招募/留住不同和服务不足的社区。这包括公众和医生教育、社区参与、基于马里兰州一个已被证明的模式的研究和宣传。沿着这些路线，我们计划：利用非传统方法：社区卫生工作者（chw）作为临床试验教育者和其他渠道，如非洲裔美国人报纸，信仰组织和地区卫生教育中心（AHECS），以接触种族/少数民族和农村人口；提高卫生知识、文化能力和语言能力，作为卫生保健系统导航的核心组成部分。目标3：在中心现场开展生物伦理学及相关的教育和培训项目和轮岗。这些项目将针对hbcu、公众、政策制定者、社区领袖和其他利益相关者；目标4：促进与其他机构、组织或团体的合作，包括NIH生物伦理部和ICDs、国家AHEC组织和国家农村卫生协会。该中心的主要合作伙伴是：巴尔的摩时报报纸和全国报纸出版商协会；东部海岸和西部的农村医疗保健中心，东部海岸癌症研究网络；鲍伊州立大学马里兰中心；社区外展工作者协会；马里兰州南部农村的Bel Alton社区学校；以及马里兰州内科医师学会。马里兰大学通过“GO”拨款RFA-OD-09-004，在NCMHD ARRA科学优先领域“生物伦理研究基础设施计划”下提交了建立生物伦理中心的申请。该中心将支持生物伦理学的综合方法，临床试验参与和研究参与的多样性。通过这种方法和目标，我们将支持国家研究企业在整个连续体中的加速发展。该中心的目标和项目与ARRA GO拨款的意图一致，包括：创造就业机会，促进当地服务不足社区的经济投资。

DESCRIPTION (provided by applicant): Program Abstract/Summary: The University of Maryland Baltimore is submitting this application to establish a Bioethics Center under the NCMHD ARRA Scientific priority area "Bioethics Research Infrastructure Initiative" through "GO" grants RFA-OD-09-004. This Bioethics Center's programs and research are based on a tested, proven model for increasing availability/participation of rural and urban cancer patients in clinical trials and research in general, which resulted in a US DHHS National Best Practice award. The model, combines specific clinical trial accrual and barrier research, education and training for the general public, patients, health professionals (i.e. physicians and policy, which will address and resolve barriers to recruitment of diverse communities in trials in the State of Maryland and in the US). Our demonstrated success with achieving diversity in clinical trial accrual includes a 40% accrual rate of African Americans in cancer center trials, a 25% rural African American accrual in cancer trials (therapeutic, prevention and control), a 20 fold increase in trial availability and a 40 fold increase in rural cancer patient accrual in a five-year period. The Center will support a comprehensive approach to bioethics, diversity in clinical trial participation and participation in research. Through this approach and the aims, we will support the acceleration of the national research enterprise across the continuum. RELEVANCE TO AIMS FOR ARRA and GO Grants: The Center aims and programs are consistent with the intent of the ARRA GO grant funding and include: 1. Creates jobs and promotes economic investment; 2. Provides investments in economy of local underserved communities; 3. Fosters community capacity enhancement/participation in the national research enterprise thus fostering the acceleration of advances in science, public health and medicine; 4. Enhances community capacity, prevents layoffs and establishes local leadership in ongoing economies; 5. Is groundbreaking, innovative, high impact and cross-cutting research that can be readily deployed and will improve and accelerate biomedical research; and 6. Includes creative approaches to overcome barriers to basic, translational, or clinical research. CENTER GOALS AND AIMS: The goal for this Center is to maximize the diversity of participants in clinical trials. The aims are: Aim 1: To establish a nationally-recognized bioethics center dedicated to fostering greater participation of racial and ethnic minority and rural populations in clinical trials; and Aim 2: To expand, further develop and implement a comprehensive approach to enhance recruitment/retention of diverse and underserved communities in research including clinical trials. This includes public and physician education, community engagement, research and advocacy based on a proven model in Maryland. Along these lines we plan to: Utilize non-traditional methods: Community Health Workers (CHWs) as clinical trial educators and other channels such as African American newspapers, faith based organizations and Area Health Education Centers (AHECS) to reach racial/ethnic minority and rural populations.; Improve health literacy, cultural competency and linguistic proficiency as a core component Of Navigation Of The Health Care System.; Aim 3: To conduct bioethics and related education and training programs and rotations on-site at the Center. These programs will be targeted to HBCUs, the general public, policy makers, community leaders, and other stakeholders; Aim 4: Foster collaboration with the other institutions, organizations, or groups including the NIH Bioethics Department and ICDs, the National AHEC Organization, and National Rural Health Association. Key partners for the Center are: Times Newspapers in Baltimore and National Newspaper Publishers Association; rural Eastern Shore and Western MD AHECs, Eastern Shore Cancer Research Network; Maryland Center at Bowie State University; Community Outreach Workers Association; Bel Alton Community School in rural Southern MD; and the Maryland Academy of Physicians. The University of Maryland submits this application to establish a Bioethics Center submitted under NCMHD ARRA Scientific priority area "Bioethics Research Infrastructure Initiative "through "GO" grants RFA-OD-09-004. The Center will support a comprehensive approach to bioethics, diversity in clinical trial participation and participation in research. Through this approach and the aims, we will support the acceleration of the national research enterprise across the continuum. The Center aims and programs are consistent with the intent of the ARRA GO grant funding and include: creation of jobs and to promote economic investment in local underserved communities.