Bladder Wall Remodeling in LUTS

宾夕法尼亚大学乔治·M·奥布莱恩泌尿学研究中心题为《膀胱壁 LUTS的重塑“有三个关键要素：1)五个主要研究人员的实验室和他们的 它带来了分子生物学、细胞生物学、神经科学、生物化学、生理学、 药理学和病理学；2)行政核心(核心A)，提供行政和财政 对单个项目内的研究进行监督、质量控制，并协调研究和 中心的相互作用，3)膀胱组织核心(核心B)作为平滑肌组织的来源 取自兔、大鼠和小鼠的LUT(正常和梗阻的膀胱和尿路)。此外，我们还有 教育和丰富以及试点和可行性(P&F)计划，以吸引年轻研究人员和 在其他生物医学领域和泌尿学研究领域工作的资深研究人员。这四个项目是：1) 《社会压力导致的排尿功能障碍：排尿功能障碍的模型》，来自丽塔·华伦天奴，2) Pam Howard的《尿路上皮结构改变后的膀胱壁重塑》(与 纽约大学孙东天博士)，3)题为《梗阻所致逼尿肌重塑的机制： Samuel K.Chacko的《低氧与拉伸》，以及4)题为《细胞外基质变化对 此外，我们还有两个P&F项目，一个来自邵华昌 题为《女性的尿道功能：雌激素的作用》和吉娜·诺辛顿的题为《作用》。 PBOO和雌激素对雌性兔逼尿肌的影响。 目的：阐明社会应激和多溴联苯并三苯氧胺(PBOO)引起大鼠脑内神经细胞功能和结构改变的机制。 通向LUTS的膀胱壁。这些研究将为儿童排尿功能障碍提供一个有用的模型。 阐明了更年期妇女和老年男性BPH所致排尿功能障碍的分子基础。 PBOO。更好地理解结构和功能变化的基本机制 LUTS患者的膀胱壁和尿路病变将有助于制定针对改变的治疗策略 导致下尿路功能改变的分子事件。

The George M. O'Brien Urology Research Center at the University of Pennsylvania entitled "Bladder Wall Remodeling in LUTS " has three key elements: 1) the laboratories of five principal investigators and their Co-Is that bring expertise in molecular biology, cellular biology, neuroscience, biochemistry, physiology, pharmacology, and pathology; 2) an Administrative Core (Core A) to provide administrative and fiscal oversight, quality control for the research within individual projects and coordination of the research and interactions in the Center, 3) a Bladder Tissue Core (Core B) to serve as resource for smooth muscle tissue of the LUTS from rabbits, rats, and mice (normal and obstructed bladders and urethra). In addition, we have Educational & Enrichment and Pilot and Feasibility (P&F) programs to attract young investigators and established investigators working in other biomedical areas to urologic research. The four projects are: 1) "Social-stress-induced urinary dysfunction: A model of dysfunctional voiding" from Rita Valentino, 2) "Bladder wall remodeling following alteration of urothelial structure" from Pam Howard (in collaboration with Dr. Tung-Tien Sun at NYU), 3) entitled "Mechanism for obstruction-induced detrusor remodeling: Role of hypoxia & stretch" from Samuel K. Chacko, and 4) entitled "Extracellular Matrix Changes in Response to Obstruction" from Edward Macarak. In addition, we have two P&F projects, one from Shaohua Chang entitled "Urethral function in females: A Role for estrogen" and one from Gina Northington entitled "The effect of PBOO and estrogen on detrusor smooth muscle in female rabbits." The focus of this O'Brien Program is to elucidate the mechanism for social stress- and PBOO-induced functional and structural changes in the bladder wall leading to LUTS. These studies will provide a useful model for dysfunctional voiding in children and elucidate the molecular basis for urinary dysfunction in menopausal women and aging men with BPHinduced PBOO. A better understanding of the basic mechanisms for alteration of the structure and function of the bladder wall and urethra in LUTS would help to develop therapeutic strategies targeting altered molecular events that cause altered function in the lower urinary tract.