Chemically amplified response strategies for medical sciences; concepts borrowed

描述(由申请人提供) 摘要：将研究一种新的策略，即在生命系统中非侵入性地诱导多光子驱动过程的放大响应策略。这一战略应该能够实现光学，从而远程控制或激活生命系统内的材料和物质，而深度控制以前是无法实现的。这种远程控制的影响是巨大和广泛的，使得以前的侵入性程序可以非侵入性地执行，并且以前无法到达的目标部位可以到达进行治疗和诊断。多光子现象允许无与伦比的时空控制，在使用较长波长的情况下，可以更深入地渗透到混浊的大宗介质中，如组织。尽管这一现象对神经科学、显微镜和光刻技术产生了革命性的影响，但通常很难在体内应用这项技术来刺激生物材料、诊断和药物输送系统。目前还没有关于体内多光子响应材料的系统报道。人们的信条是，没有足够多的光子可以到达材料，从而引发反应。我们打算探索的一种策略是放大响应策略，这一策略的灵感来自于一种随着用于制造计算机芯片的化学放大光致抗蚀剂的出现而彻底改变了电子工业的策略。当重复嵌入材料中的单个响应分子单元同时吸收两个光子时，该分子单元的变化将引起多米诺骨牌效应，将整个材料作为一个整体解体。它几乎就像一件编织的套头衫；拉上一点松散的线，整个事情就会解开。 与公共卫生相关：远程控制生命系统内植入或循环材料的行为的影响是巨大和广泛的，使得以前的侵入性程序可以非侵入性地执行，并且以前无法接触到的目标组织可以到达进行治疗和诊断。

DESCRIPTION (Provided by the applicant) Abstract: A new strategy, an amplified response strategy for inducing multi photon driven processes non-invasively in living systems, will be investigated. This strategy should enable optical and thus remote control or activation of materials and substances inside living systems non-invasively with depth control previously unattainable. The impact of such remote control is large and broad allowing previously invasive procedures to be performed non-invasively, and previously inaccessible target sites to be reached for both treatment and diagnosis. The multi photon phenomena allowed unparalled spatio temporal control, and where longer wavelengths were employed, deeper penetration into turbid bulk media such as tissue. Despite the revolutionary impact this phenomena has had on neuroscience, microscopy and lithography, it has been generally very difficult to apply this technique in vivo to stimulate biomaterials, diagnostics and drug delivery systems. Currently there are no reported systems for in vivo multi photon responsive materials. The dogma is that not enough photons can reach the materials to initiate a response. A strategy we aim to explore is the amplified response strategy, a strategy inspired by one that has revolutionized the electronics industry with the advent of chemically amplified photoresists for fabrication of computer chips. When a single responsive molecular unit, repetitively embedded in a material, simultaneously absorbs two photons, the changes in that molecular unit will cause a domino effect that will unravel the entire material as a whole. It is almost like a knitted jumper; pull on a bit of loose thread and the whole thing unravels. Public Health Relevance: The impact of remote control over the behavior of implanted or circulating materials inside living systems is large and broad allowing previously invasive procedures to be performed non-invasively, and previously inaccessible target tissue to be reached for both treatment and diagnosis.