Anxiety Vulnerability and Smoking Cessation

描述（由申请人提供）：当前提案的主要目标如下：1.a。为了验证这一假设，即与焦虑敏感性（AS）较低的吸烟者相比，焦虑敏感性（AS）较高的吸烟者在自我引导的戒烟尝试中表现得更不成功，如下所示：1)首次吸烟时间较短；(1.。2)戒烟后1周、2周、4周和12周的点患病率较低。1. b。为了验证AS与戒烟/复吸之间的关联是由特定的情绪和吸烟过程介导的，包括：(1)b。1)在尝试戒烟期间，负面情绪强度更高；(1. b。2)在戒烟过程中尼古丁戒断症状的强度更高。公共卫生相关性：目前的建议填补了吸烟-精神病学文献中临床和理论相关的空白，正如最近NIMH吸烟-精神病学脆弱性报告所支持的那样（Ziedonis等人，出版中）。事实上，这项研究的结果将直接为as吸烟模型提供信息，并更普遍地作为具体的焦虑相关过程如何维持吸烟行为的例证。这项拟议的研究是一项具有临床意义的创新试验，旨在了解吸烟消失和复发的机制。

DESCRIPTION (provided by applicant): The primary objectives of the current proposal are as follows: 1.a. To test the hypothesis that smokers characterized by higher compared to lower Anxiety Sensitivity (AS) will demonstrate less success in a self-guided cessation attempt, as indexed by: (1.a.1) Shorter time to first smoking lapse; (1.a.2) Lower point-prevalence abstinence at one, two, four, and 12 weeks post-quit date. 1.b. To test the hypothesis that the association between AS and lapse/relapse to smoking is mediated by the specified emotion and smoking-based processes, including: (1.b.1) Greater levels of negative affect intensity during the cessation attempt; (1.b.2) Greater levels of nicotine withdrawal symptom intensity during the cessation attempt. PUBLIC HEALTH RELEVANCE: The present proposal fills a needed clinically- and theoretically-relevant gap in the smoking- psychiatric literature, as recently espoused by the current NIMH smoking-psychiatric vulnerability report (Ziedonis et al., in press). Indeed, results of the proposed study will directly inform AS-smoking models, and serve more generally as an illustration of how specific anxiety-related processes serve to maintain smoking behavior. The proposed investigation represents a clinically significant and innovative test for a program of research aimed at understanding the mechanisms underlying smoking lapse and relapse.