Optimising benefits and minimising potential harms of obesity treatments

这项工作旨在为全球超过21亿超重或肥胖者找到安全和更有效的肥胖治疗方法。严格的能量限制饮食是目前最有效的饮食肥胖治疗方法，但由于担心潜在的危害，这些饮食没有得到充分利用。这项工作将研究间歇性而不是连续地使用严格饮食，以此作为一种手段，在减少潜在有害影响的同时，增强其长期减肥的好处。

This work aims to find safe and more effective obesity treatments for the over 2.1 billion people worldwide with overweight or obesity. Severely energy restricted diets are currently the most effective dietary obesity treatment, but these are underutilized due to concerns about potential harms. This work will investigate using severe diets intermittently rather than continuously, as a means of enhancing their benefits of long-term weight/fat loss while also reducing potential harmful effects.