SEROLOGICAL MARKERS OF PERIODONTAL DISEASE AND PANCREATIC CANCER RISK

描述（由申请人提供）：胰腺癌是癌症相关死亡的第四大原因，具有高度致死性; 95%的胰腺癌患者在初次诊断后5年内死亡。了解胰腺癌的病因对于实施预防措施至关重要，同时可以提供如何治疗和检测这种恶性肿瘤的见解。目前对胰腺癌的病因知之甚少;吸烟、慢性胰腺炎、家族综合征和其他可疑的危险因素只能解释所有胰腺癌病例的25-30%。几项研究支持牙周炎和胰腺癌风险之间的关联;在最近的一篇出版物中，在一个大型的前瞻性健康专业人员队列中，在从不吸烟者中观察到这种关联。如果得到证实，对这种联系的影响是巨大的，将包括需要作出更多努力来了解基本机制。由于牙周病很难在流行病学环境中进行测量，我们建议使用牙周微生物抗体，以有效和快速的方式阐明这种关联的可行性。此外，我们的方法将避免与使用牙周病的自我报告或使用牙周病的回顾性评估在病例对照设置的测量误差的关注。我们的研究将能够直接解决牙周感染是否存在于癌症发作之前的问题，因为所有的血液都是在诊断前收集的。对于这项研究，我们建议测量四种常见牙周细菌病原体和厌氧菌的抗体，这些细菌与胰腺炎有关，也是口腔微生物组的一部分。将使用来自欧洲癌症前瞻性研究（EPIC）队列研究的468例胰腺癌病例和匹配对照来检查检测的抗体与胰腺癌之间的关联。本研究提供了胰腺癌风险因素的详细数据，并将其纳入分析中以控制潜在的混杂因素。这项研究将提供有价值的数据，以进一步评估牙周病在胰腺癌病因学中的潜在作用，并可能为预防这种高度致命的癌症提供一个新的研究领域。 公共卫生相关性：这项研究将为牙周病和胰腺癌风险提供有价值的数据，并可能为这种高度致命的癌症开辟一个新的研究领域。此外，这项研究的发现可能会导致对胰腺癌机制的深入了解，这可能会转化为预防建议或治疗，从而降低这种高度致命的恶性肿瘤的发病率和死亡率。

DESCRIPTION (provided by applicant): Pancreas cancer is the fourth leading cause of cancer-related death and is highly lethal; 95% of patients with this cancer die within 5 years of initial diagnosis. Understanding the etiology of pancreatic cancer is critical to implement steps towards prevention and may concurrently provide insights on how to treat and detect this malignancy. Little is known about the causes of pancreatic cancer; tobacco smoke, chronic pancreatitis, familial syndromes, and other suspected risk factors can only explain 25-30% of all pancreatic cancer cases. Several studies support an association between periodontitis and pancreatic cancer risk; in a recent publication, this association was observed among never smokers in a large prospective cohort of health professionals. The implications for this association, if confirmed, are substantial and will include the need for more efforts towards understanding the underlying mechanisms. As periodontal disease is difficult to measure in epidemiologic settings, our proposal to use antibodies to periodontal organisms should shed light on the plausibility of this association in an efficient and rapid fashion. Furthermore, our approach will avoid concerns of measurement error related to use of self-report of periodontal disease or use of retrospective assessment of periodontal disease in a case-control setting. Our study will be able to directly address the question of whether periodontal infection was present before the cancer onset as all bloods were collected pre-diagnostically. For this study, we propose to measurement antibodies to four common periodontal bacterial pathogens and to anaerobic bacteria that have been linked to pancreatitis and are also part of the oral microbiome. The association between the antibodies tested and pancreatic cancer will be examined using 468 pancreatic cancer cases and matched controls from the European Prospective Investigation into Cancer (EPIC) cohort study. Detailed data on risk factors of pancreatic cancer are available in this study and will be included in the analysis to control for potential confounding. This study should provide valuable data to further evaluate the potential role of periodontal disease in the etiology of pancreatic cancer and may provide a new area of research for the prevention of this highly fatal cancer. PUBLIC HEALTH RELEVANCE: This study will provide valuable data on periodontal disease and pancreatic cancer risk and may open a new area of research for this highly fatal cancer. In addition, findings from this study could lead to insights into the mechanism of pancreatic cancer which may translate into prevention recommendations or treatments that could reduce the incidence and mortality from this highly lethal malignancy.