INTERACTORS OF GDOWN1

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的合作者先前已经从组织提取物中分离出一种独特而丰富的哺乳动物Pol II亚群，该亚群含有一种额外的紧密相关的多肽Gdown 1。他们的研究结果表明，含有Gdown 1的Pol II（称为Pol II（G））选择性依赖于并响应于Mediator。我们目前正在对与Gdown 1相互作用的蛋白质进行彻底的质谱分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our collaborators have previously isolated from tissue extracts a distinct and abundant mammalian Pol II subpopulation that contains an additional tightly associated polypeptide, Gdown1. Their results established that Gdown1-containing Pol II, designated Pol II(G), is selectively dependent on and responsive to Mediator. We are currently carrying out a thorough mass spectrometric analysis of proteins that interact with Gdown1