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Autophagy as a component of the innate immune response

Autophagy as a component of the innate immune response
自噬作为先天免疫反应的一个组成部分
批准号：
7837483
负责人：
MICHELE Somes SWANSON
金额：
$37.41万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-08-14 至 2011-08-31
来源：
https://reporter.nih.gov/project-details/7837483
关键词：
Alveolar MacrophagesAmino AcidsAutophagocytosisAutophagosomeBacteriaBiological AssayC57BL/6 MouseCaspase-1Cell DeathCommitComplexCytolysisCytoplasmDataDevelopmentDoseEnzyme-Linked Immunosorbent AssayEpitopesFlagellinFluorescence MicroscopyGeneticHumanImmune responseImmune systemInfectionInflammatoryInterleukin-18KnowledgeLegionella pneumophilaLeukocytesLifeLungLysosomesMammalian CellMicrobeMicroscopyMolecularMusNatural ImmunityNutrientPathway interactionsPatternProteinsRouteSignal TransductionStarvationTestingToll-like receptorsVirulenceVirulentWithdrawalabstractingdeprivationmacrophagemicrobialmutantparticlepathogenrespiratoryresponsetooltrait

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中文摘要
翻译
摘要 先天免疫领域的一个令人兴奋的发展是发现巨噬细胞 利用自噬来保护细胞质免受感染长期以来， 已知会诱导自噬，但感染如何快速触发这种替代途径， 对消化溶酶体了解甚少。遗传学数据表明，小鼠抵抗L。 通过依赖NOD样蛋白来检测细胞溶质鞭毛蛋白， 然后通过自噬来消化微生物， 也就是焦亡为了确定巨噬细胞如何整合自噬和 作为微生物感染的屏障，我们将利用嗜肺军团菌作为 先天免疫系统的基因探针
英文摘要
Abstract An exciting development in the innate immunity field is the discovery that macrophages enlist autophagy to protect their cytoplasm from infection. Nutrient deprivation has long been known to induce autophagy, but how infection rapidly triggers this alternate route to digestive lysosomes is poorly understood. Genetic data indicate that mice resist L. pneumophila infection by relying on NOD-like proteins to detect cytosolic flagellin and then to digest the microbes by autophagy or to commit a pro-inflammatory cell death known as pyroptosis. To determine how macrophages integrate autophagy and pyroptosis as barriers to microbial infection, we will exploit Legionella pneumophila as a genetic probe of the innate immune system.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection.
DOI： 10.1128/mbio.00620-12
发表时间： 2013-02-12
期刊： mBio
影响因子： 6.4
作者： [Byrne BG, Dubuisson JF, Joshi AD, Persson JJ, Swanson MS]
通讯作者： Swanson MS
Secrets of a successful pathogen: legionella resistance to progression along the autophagic pathway.
DOI： 10.3389/fmicb.2011.00138
发表时间： 2011
期刊： Frontiers in microbiology
影响因子： 5.2
作者： [Joshi AD, Swanson MS]
通讯作者： Swanson MS
2014 Microbial Toxins and Pathogenicity Gordon Research Conference & Gordon Resea
  • 批准号：
    8782883
  • 项目类别：
  • 资助金额：
    $0.8万
  • 财政年份：
    2014
  • 负责人：
    MICHELE Somes SWANSON
  • 依托单位：
    GORDON RESEARCH CONFERENCES
Analysis of L. Pneumophilia Virulence Regulation
FASEB Summer Research Conference "Microbial Pathogenesis: Mechanisms of Infectio
Autophagy as a component of the innate immune response
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