Administrative Core

行政核心将为AADCRC U19中心计划的所有项目和核心提供服务，并将 由大卫·佩登博士指导，私家侦探为这个U19项目。关于数据的生物统计学支持和建议 生物统计核心主任周海波博士将通过这一核心提供管理 北卡罗来纳大学环境医学、哮喘和肺生物学中心(佩登博士是该中心的主任)。 数据管理支持将由该核心提供，该核心由NIH和EPA基金资助。这个 行政核心将负责日常行政和计划协调，并 正在对U19进行评估。行政核心的职能将包括所有行政和 财务方面，包括及时支付资金、提交报告、汇编和 跟踪计划材料和报告，并安排所有核心和 U19的项目。佩登博士将作为首席调查员参加指导委员会的会议 以及AADCRC的其他活动。行政核心预算包括校长的差旅费。 调查员参加指导委员会的年度会议，以及PI、核心和项目 领导人将出席为期两天的AADCRC年度科学会议，该会议将与 指导委员会在马里兰州贝塞斯达举行会议。协调项目的临床相关性将 由Peden博士监督，他将审查并协助制定所有临床研究方案 IRB、GCRC和EPA。来自动物研究的数据将为这些方案的发展提供信息。每周 方案审查会议和实验室会议将由Peden博士和Ting博士主持，他们将为 作为U19的协力派。佩登博士还将协调对现有NIH资助样本的访问 环境医学、哮喘和环境医学中心的采集、分析和储存库核心设施 肺生物学(由Alexis博士领导)。这些现有的岩芯将为样品分析提供支持 用于通过呼吸道和血细胞的流式细胞术分析呼吸道液体中的核苷酸和可溶性蛋白质。

The Administrative Core will serve all Projects and Cores of AADCRC U19 Center Program and will be directed by Dr. David Peden, P.I. for this U19 program. Biostatistical support and advice on data management will be provided through this core by Dr. Haibo Zhou, Director of the Biostatistics Core for the UNC Center for Environmental Medicine, Asthma & Lung Biology (of which Dr. Peden is the Director). Data management support will be provided by this core which is funded by NIH and EPA funds. The Administrative Core will be responsible for the day-to-day administration and program coordination and ongoing evaluation of the U19. The functions of the Administrative Core will include all administrative and financial aspects which will include the timely disbursal of funds, submission of reports, assembling and keeping track of program materials and reports, and scheduling meetings of all leaders of Cores and Projects of the U19. Dr. Peden, as Principal Investigator will participate in Steering Committee meetings and other AADCRC activities. The Administrative Core budget includes travel funds for the Principal Investigator to participate in annual Steering Committee meetings, and for the PI and Core and Project leaders to attend an annual two-day AADCRC scientific meeting to be held in conjunction with the Steering Committee meeting in Bethesda, Maryland. Coordination of clinical relevance of the projects will be overseen by Dr. Peden who will review and assist in development of all clinical research protocols with the IRB, GCRC and EPA. Data from animal studies will inform development of these protocols. Weekly protocol review meetings and lab meetings will be conducted by Dr. Peden and Dr. Ting, who will serve as the Co-Pi of the U19. Dr. Peden will also coordinate access to existing NIH funded Sample Acquisition, Analysis, and Repository Core Facility of the Center for Environmental Medicine, Asthma & Lung Biology (headed by Dr. Alexis). These existing cores will provide support for sample analysis of nucleotides in airway fluids and for soluble protein profiling by flow cytometry of airway and blood cells.