Research Training in Allergy and Clinical Immunology

过敏和临床免疫学研究培训

• 批准号: 10686797
• 负责人: David B. Peden
• 金额: $ 44.39万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-19 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686797
• 关键词: Clinical Immunology; Hypersensitivity; Research Training

Abstract The goal of this project is to develop innovative physicians and PhD scientists trained in the latest methods of laboratory, translational and clinical research and fully prepared to pursue independent research careers investigating critical issues in Allergy and Immunology (A/I). For over 40 years this program has produced leaders in the field of A/I. This application maintains the training collaboration established between the complementary A/I training programs at Duke University and The University of North Carolina Chapel Hill (UNC). The combined strength of their A/I programs and their respective Universities create an ideal venue for training the next generation of A/I investigators. This proposal continues a highly innovative program for both physicians and PhD trained scientists in translational research in immune- based diseases. These goals will be accomplished through 1) formal courses in clinical research design, 2) rigorous training in basic immunology and 3) a structured mentorship program. Our research emphasis areas are designed to address these future needs in the field: 1) Human Immune Response to Pathogens, 2) Immunobiology of Food Allergy and 3) Pathobiology of Asthma, Respiratory and Allergic Disease. Mentors were selected from highly integrated and focused programs currently in place at Duke and UNC who demonstrated research productivity. Additionally, in this cycle we will bring an increased focus to Diversity, Equity and Inclusion as well as the mentor development of junior faculty who will become future established mentors. This application requests support for five trainees each year. Fulfillment of the program's objective would directly or indirectly serve to meet two urgent medical needs: 1) the need for more full-time researchers and teachers of allergy and clinical immunology in medical schools throughout the country and 2) the need for more physicians trained in the specific care of patients with allergic and immunologic disorders.

摘要 该项目的目标是培养受过最新治疗方法培训的创新内科医生和博士科学家。 实验室、转译和临床研究，并为从事独立研究事业做好充分准备 研究过敏和免疫学的关键问题(A/I)。40多年来，这个项目培养了一批领导者 在A/I领域，该应用程序维护在互补的 杜克大学和北卡罗来纳大学教堂山分校(UNC)的A/I培训计划。这个 他们的A/I课程和各自的大学的优势相结合，创造了一个理想的培训场所 下一代A/I调查员。这项提案延续了一项高度创新的计划， 医生和博士培训科学家进行基于免疫的疾病的转化研究。这些目标 将通过1)临床研究设计的正式课程，2)基础的严格培训来完成 免疫学和3)结构化的导师计划。我们的研究重点领域旨在 满足这些领域未来的需求：1)人类对病原体的免疫反应，2)免疫生物学 食物过敏和3)哮喘、呼吸道和过敏性疾病的病理生物学。导师是从 杜克大学和北卡罗来纳大学目前实施的高度整合和重点突出的计划展示了研究 生产力。此外，在这个周期中，我们还将更加关注多样性、公平和包容性 作为导师发展的初级教员将成为未来既定的导师。此应用程序 要求每年支持五名受训人员。计划目标的实现将直接或间接地 用于满足两个紧急的医疗需求：1)需要更多的全职过敏研究人员和教师以及 全国医学院的临床免疫学和2)需要更多受过培训的医生 在过敏性和免疫性疾病患者的特殊护理中。

项目成果

The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch.

上皮细胞来源的特应性皮炎细胞因子 TSLP 激活神经元以诱发瘙痒。

• DOI: 10.1016/j.cell.2013.08.057
• 发表时间: 2013-10-10
• 期刊: Cell
• 影响因子: 64.5
• 作者: Wilson SR;Thé L;Batia LM;Beattie K;Katibah GE;McClain SP;Pellegrino M;Estandian DM;Bautista DM
• 通讯作者: Bautista DM

Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization.

• DOI: 10.1016/j.jaci.2010.12.1083
• 发表时间: 2011-03
• 期刊: The Journal of allergy and clinical immunology
• 作者: Kim EH;Bird JA;Kulis M;Laubach S;Pons L;Shreffler W;Steele P;Kamilaris J;Vickery B;Burks AW
• 通讯作者: Burks AW

Pathogenesis of food allergy in the pediatric patient.

• DOI: 10.1007/s11882-012-0296-x
• 发表时间: 2012-12
• 期刊: CURRENT ALLERGY AND ASTHMA REPORTS
• 影响因子: 5.5
• 作者: Chin, Stacy;Vickery, Brian P.
• 通讯作者: Vickery, Brian P.

What Is the Cause of the Chronic Erythematous Scaling Plaques on This 22-Month-Old Girl and Her Family?

这位 22 个月大的女孩及其家人出现慢性红斑鳞屑的原因是什么？

• DOI: 10.1177/0009922817738347
• 发表时间: 2018
• 期刊: Clinical pediatrics
• 影响因子: 1.6
• 作者: Ro,Teresa;Sood,Amika;Kelly,KevinJ;Morrell,DeanS
• 通讯作者: Morrell,DeanS

Achieving the Quadruple Aim to deliver value-based allergy care in an ever-evolving health care system.

• DOI: 10.1016/j.anai.2020.04.007
• 发表时间: 2020-08
• 期刊: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
• 作者: Iglesia EGA;Greenhawt M;Shaker MS
• 通讯作者: Shaker MS