Faculty Recruitment and Core Resource Development in Stem Cell Biology

描述(申请人提供)：这项P30申请的总体目标是通过干细胞资源的开发来提高对心血管、肺和血液疾病的理解和治疗的研究能力。为了实现这一目标，我们建议招聘并聘用朴仁贤博士为新成立的发育生物学系的终身教员，以直接响应RFA-OD-09-005《复苏法案有限竞争：支持新教师招聘以通过生物医学研究核心中心增强研究资源》(P30)。Park博士在干细胞研究方面拥有丰富的经验，并从多种疾病的患者中培养出了一些第一批诱导的多能干细胞(IPS)。Park博士的成功招聘，以及后来其他高素质终身教职教师的成功招聘，将通过开发新的干细胞核心来加强。因此，P30提案的三个具体目标包括：1.在干细胞生物学领域招聘新的终身教职跟踪教师；2.创建一个干细胞核心，通过大学范围内共享的干细胞生产和分配资源来支持和加强干细胞研究；以及3.通过干细胞核心创建一个用于人员培训和新干细胞技术开发的管道，以加强干细胞研究。Park博士将担任干细胞核心的主任，为核心提供科学监督。他将由一名助理主任协助管理核心的日常活动。一个由大学不同系/科的教师组成的咨询委员会将组成一个咨询委员会，以协助制定管理核心的政策。这将包括对与人类干细胞研究有关的伦理问题的指导。此外，还将组建一个重叠的指导委员会，以协助朴博士制定教师发展计划，并就如何平衡朴博士的研究需求与核心的其他需求并确定其优先顺序提供指导。这种管理和领导结构将提高新教师的研究效率，同时促进其他对干细胞研究感兴趣的教师的工作。 总体而言，Park博士的招聘、干细胞核心的建立以及发育生物学系的创建反映了该大学对生物医学研究的多学科方法，并填补了干细胞资源方面的空白。在Ranges研究中心的新部门中放置干细胞核心将鼓励将基础科学研究与发展机制与疾病机制的临床研究相结合。总而言之，这些努力的成功实施将促进基于干细胞的跨学科转化研究和新的创新疗法的开发。

DESCRIPTION (provided by applicant): The overarching goal of this P30 application is to enhance research capacity in the understanding and treatment of cardiovascular, pulmonary, and blood diseases through the development of stem cell resources. To accomplish this, we propose to recruit and hire Dr. In-Hyun Park as tenure tract faculty in the newly formed Department of Developmental Biology, in direct response to RFA-OD-09-005 "Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers" (P30). Dr. Park possesses a wealth of experience in stem cell research and has generated some of the first induced pluripotent stem (iPS) cells from patients with a wide range of diseases. The successful recruitment of Dr. Park, and later, other highly qualified tenure tract faculty will be augmented by the development of a new Stem Cell Core. Hence, the three specific aims of this P30 proposal comprises: 1. Recruit new tenure track faculty in the field of stem cell biology, 2. Create a Stem Cell Core to support and enhance stem cell research via a university-wide shared resource for the production and distribution of stem cells, and 3. Create through the Stem Cell Core, a pipeline for personnel training and development of new stem cell technologies to enhance stem cell research. Dr. Park will serve as the Director of the Stem Cell Core, providing scientific oversight for the Core. He will be assisted by an assistant director who will manage the day to day activities of the Core. An advisory committee comprised of faculty from different departments/divisions of the University will be assembled to assist with establishing policies for running the core. This will include guidance on ethics issues related to human stem cell research. In addition, an overlapping mentoring committee will be assembled to assist Dr. Park with a faculty development plan and to provide guidance on balancing and prioritizing Dr. Park's research needs with other demands of the Core. This administrative and leadership structure will enhance the research productivity of the new faculty recruit, and at the same time, facilitate the work of other faculty interested in stem cell research. Overall, the recruitment of Dr. Park, the establishment of this Stem Cell Core, and the creation of the Dept of Developmental Biology reflect the University's multidisciplinary approach to biomedical research, and fills a gap that exists with respect to stem cell resources. Placement of the Stem Cell Core in the new Department at the Ranges Research Center will encourage the integration of basic science investigation into developmental mechanisms with clinical investigation into disease mechanisms. Together, the successful implementation of these endeavors, will promote interdisciplinary stem cell based translational research and the development of new, innovative therapies.