Metabolism in Heart Failure Translational Research Center

描述(由申请人提供)：哥伦比亚大学医学中心(CUMC)包含基础心血管研究和临床心力衰竭的几个大型研究项目。为了响应这一P30计划，医学部和心血管研究计划(CVRI)挑选了一名最近招聘的新教师，其终身教职将于2009年7月1日开始。我们被推荐的新教员正在完成他在CUMC项目中的心脏病学培训，这是全国最有选择性的项目之一。在此之前，他对骨骼肌的基本生物学及其在心力衰竭患者中的异常进行了研究。拟议的研究包括心力衰竭对肌肉生物学的影响的临床和基础研究，重点是蛋白质周转和脂肪代谢。这一应用的中心假设是，常见的基因表达模式和代谢紊乱决定了心力衰竭患者骨骼肌和心肌的结构和功能变化，并且这些变化在通过放置心室辅助装置改善血流动力学后是可逆的。CUMC的一系列高级合作者将协助这些研究。为了确保这次招聘的成功，已经制定了一个职业指导计划，其中包括来自几个系的教职员工。这笔赠款的资金将用于购买设备，为拟议的临床和基础研究提供运营费用，并将允许雇用支助人员协助进行两年的研究。医学部和心脏病司承诺提供额外资金，以保证五年的全额工资支持和一些实验室运营费用。该部门和CVRI的一个主要目标是增加我们在心血管疾病方面的临床和研究活动之间的互动。此次招聘是通过增加一名专注于翻译研究的杰出新教师来实现这一目标的努力。 心力衰竭是一种在全球范围内蔓延的流行病，已经影响到美国500多万人。运动不耐受和肌肉萎缩是外周新陈代谢受损的结果，是心力衰竭死亡率的预测指标。本研究旨在了解骨骼肌与心肌代谢和功能的基本相互作用，最终目的是发现新的治疗方法来预防或治疗心力衰竭患者的功能衰退。

DESCRIPTION (provided by applicant): Columbia University Medical Center (CUMC) contains several large research programs in basic cardiovascular research and clinical heart failure. In response to this P30 program, the Department of Medicine and the Cardiovascular Research Initiative (CVRI) have selected a recently recruited new faculty member whose tenure track appointment will begin on July 1, 2009. Our proposed new faculty member is completing his training in cardiology in the CUMC program, one of the most selective programs in the country. Prior to this he performed studies on the basic biology of skeletal muscle and its abnormalities in patients with heart failure. The proposed research includes clinical and basic studies of the effects of heart failure on muscle biology, concentrating on protein turnover and lipid metabolism. The central hypothesis of this application is that common gene expression patterns and metabolic derangements determine structural and functional changes in the skeletal muscle and myocardium of patients with heart failure, and that those changes are reversible after hemodynamic improvement through ventricular assist device placement. A series of senior collaborators at CUMC will assist in these studies. A career guidance program that includes faculty from several departments has been developed to insure the success of this recruit. Funds from this grant will support the purchase of equipment, provide operating expenses for the proposed clinical and basic research, and will allow the hiring of support staff to assist with the 2 year studies. The Department of Medicine and Division of Cardiology have committed additional funds that guarantee full salary support and some laboratory operating expenses for five years. A major goal of the Department and CVRI is to increase interaction between our clinical and research activities in cardiovascular disease. This recruitment is an effort to do that by adding an outstanding new faculty member focusing on translational research. Heart failure is an expanding worldwide epidemic that already affects more than 5 million people in the US. Exercise intolerance and muscle wasting result from impaired peripheral metabolism and are predictors of mortality in heart failure. This research aims to understand the fundamental interactions of skeletal muscle and myocardial metabolism and function with the ultimate goal of discovering new therapies to prevent or treat the functional decline in patients with heart failure.