The Biology of Integrated Nuclear and Extranuclear Steroid Signaling

描述(由申请人提供)：类固醇介导的过程传统上被认为是通过核受体转录活性的变化来调节的。然而，临床线索表明，类固醇也不依赖于转录(非基因组)来传递信号。例如，肾上腺功能不全患者的糖皮质激素治疗可以在几分钟内缓解症状并降低ACTH--太快了，无法涉及转录和随后的蛋白表达的变化。因此，现在的研究表明，类固醇可以激活快速的、核外的、转录无关的信号。虽然这些作用的重要性最初受到健康的怀疑，但类固醇的非基因组作用现在被接受参与调节许多重要的生物过程，包括增殖、凋亡、血管生成、神经元信号转导和生殖细胞发育。此外，核外和核内类固醇受体信号已被证明在协同作用中发挥作用，核外类固醇信号增强核内类固醇介导的转录。最后，对类固醇触发的、转录无关的信号通路的研究揭示了新的信号机制，这些机制目前正被用于抑制激素依赖的新的肿瘤过程。这次由FASE B和内分泌学会主办的会议的目的是将研究转录非依赖和依赖的类固醇信号的研究人员聚集在一起，努力促进串扰和合作，以及进一步统一类固醇信号领域。这次会议的三个目的是：1)回顾在核外和转录类固醇信号领域令人兴奋的新发现；2)为年轻的研究人员提供一个展示他们的工作并与类固醇信号领域的知名领导者互动的场所；以及3)讨论类固醇信号研究的重要翻译含义。 与公共健康相关：类固醇调节许多重要的生物学过程，这些过程涉及生殖、心血管健康、肾功能、肿瘤生长和神经功能。这次会议为类固醇信号方面的专家、新研究人员和受训人员提供了一个会面和讨论该领域新的和令人兴奋的发现的场所。这次会议的重点将是将基础科学发现与新的治疗方法联系起来，这些方法包括改变类固醇信号来治疗癌症或不孕不育等疾病。

DESCRIPTION (provided by applicant): Steroid-mediated processes have traditionally been thought to be regulated by changes in nuclear receptor transcriptional activity. However, clinical clues have suggested that steroids also signal independent of transcription (non-genomic). For example, glucocorticoid treatment of patients with adrenal insufficiency results in symptomatic relief and a lowering of ACTH within minutes - much too rapidly to involve changes in transcription and subsequent protein expression. Accordingly, studies have now demonstrated that steroids can activate rapid, extra-nuclear, transcription-independent signals. While the importance of these effects was first met with healthy skepticism, non-genomic actions of steroids are now accepted to participate in regulating many important biological processes, including proliferation, apoptosis, angiogenesis, neuronal signaling, and germ cell development. In addition, extra- and intra-nuclear steroid receptor signaling have been shown to work in synergy whereby extra-nuclear steroid signals enhance intra-nuclear steroid- mediated transcription. Finally, the study of steroid-triggered, transcription-independent, pathways has revealed novel signaling mechanisms that are currently being targeted to suppress hormone- dependent neo-plastic processes. The purpose of this FASEB- and Endocrine Society-sponsored conference is to bring together investigators studying both transcription-independent and -dependent steroid signaling in an effort to foster cross talk and collaboration, as well as to further unify the field of steroid signaling. The three aims of this conference are: 1) To review exciting new discoveries in the fields of both extra-nuclear and transcriptional steroid signaling; 2) To provide a venue for young investigators to present their work and interact with established leaders in the field of steroid signaling; and 3) Discuss the important translational implications of steroid signaling research. PUBLIC HEALTH RELEVANCE: Steroids regulate many important biological processes that are involved in reproduction, cardiovascular health, kidney function, tumor growth, and neurological functions. This conference provides a venue for experts, new investigators, and trainees in steroid signaling to meet and discuss the new and exciting discoveries in the field. The conference will focus on relating basic science discoveries with new therapeutic approaches that involve altering steroid signaling to treat diseases such as cancer or infertility.