Thrombospondins and other matricellular proteins in tissue organization and homeo

描述(申请人提供)：细胞与其周围的细胞外基质(ECM)之间的相互作用是所有后生生物中多细胞生命的基础，也是细胞和组织组织所必需的。结构ECM成分，如胶原蛋白、纤维连接蛋白和层粘连蛋白，由细胞分泌，并在细胞外组装成有组织的薄片(基底膜)或三维纤维和网络(结缔组织基质)。ECM还含有含量较少但受高度调控的成分，这些成分在控制细胞行为和基质重塑方面发挥着重要作用。由于它们在ECM中的独特定位和功能属性，这些蛋白被称为基质细胞蛋白，包括血栓反应蛋白、CCN、Tenascin、兄弟姐妹和SPARC家族的成员。本次会议的目的是集中于这些基质髓蛋白，并研究它们的结构-功能关系以及它们对信号网络的影响，这些信号网络在疾病、内稳态、修复和发育中发挥关键作用。通过讲座和海报会议，知名科学家和年轻的研究人员将讨论母细胞蛋白质结构和遗传学及其在组织重塑、纤维化、损伤和应激反应、发育、神经生物学、代谢调节、血管生成、炎症和免疫中的作用。该计划将侧重于糖尿病、心血管、肾脏和肌肉骨骼疾病以及癌症的翻译应用。该节目将包括受邀演讲者的长篇演讲，从以年轻科学家为特色的摘要投稿中挑选的简短演讲，以及活跃的海报会议。在制定该计划时，强调纳入女性、少数民族和年轻科学家。被邀请的演讲者代表基础科学领域的领导者、正在确定基质细胞蛋白在遗传性疾病和成人几种主要疾病的病因学中的作用的临床研究人员，以及开发治疗这些疾病的新疗法的研究人员。本次会议的总体目标是培养基质细胞蛋白领域的新知识，这将导致开发治疗人类疾病的新疗法，促进新的多学科合作和研究方向的发展，并鼓励该领域的青年科学家的发展。 公共卫生相关性：项目简介本次会议的目的是关注在所有主要身体组织中具有特定功能的一组重要的基质细胞蛋白，目前人们认识到它们在多种生理和病理生理过程中发挥作用，包括糖尿病和代谢性疾病、肾脏、心脏和肺部疾病、癌症、肌肉骨骼疾病、发育、人类遗传疾病以及炎症和伤口愈合。这次会议的目的是通过聚集活跃的研究人员和互补性专家来加强、启发和加速这一领域的基础研究及其翻译应用，否则他们将没有机会会面和交流数据、想法和试剂。重要的是，这次会议的一个目标是通过与基础和临床科学家进行有意义的互动，让他们接触到该领域最广泛的背景，从而进一步促进该领域青年科学家的发展。

DESCRIPTION (provided by applicant): Interactions between cells and their surrounding extracellular matrix (ECM) are the basis for multi-cellular life and essential for cell and tissue organization in all metazoan organisms. Structural ECM components such as collagens, fibronectin, and laminins, are secreted by cells and assembled extracellularly into organized sheets (basement membranes) or three-dimensional fibrils and networks (connective tissue matrix). ECM also contains less abundant, but highly regulated, components that play important roles in controlling cell behavior and matrix remodeling. Because of their distinctive localizations and functional attributes in the ECM, these proteins have been termed matricellular proteins and include members of the thrombospondin, CCN, tenascin, SIBLING, and SPARC families. The purpose of this conference is to focus on these matriceullular proteins and to examine their structure-function relationships and their impact on signaling networks that play key roles in disease, homeostasis, repair, and development. Through lectures and poster sessions, established scientists and young investigators will address current topics in matricellular protein structure and genetics and their roles in tissue remodeling, fibrosis, injury and stress responses, development, neurobiology, metabolic regulation, angiogenesis, inflammation, and immunity. The program will emphasize translational applications to diabetes, cardiovascular, renal, and musculoskeletal diseases, and cancer. The program will feature full length talks from invited speakers, short talks selected from abstract submissions which will feature young scientists, and robust poster sessions. Inclusion of women, minorities, and young scientists has been emphasized in developing the program. Invited speakers represent leaders in the basic sciences, clinical investigators who are defining the roles of matricellular proteins in the etiology of inherited disorders and several major diseases of adults, and investigators developing novel therapeutics to treat these diseases. The overall objectives of this meeting are to foster new knowledge in the field of matricellular proteins that will lead to development of novel therapeutics for the treatment of human diseases, facilitate the development of new multidisciplinary collaborations and research directions, and encourage the development of young scientists in this field. PUBLIC HEALTH RELEVANCE: Project Narrative The purpose of this conference is to focus on the important group of matricellular proteins that have context- specific functions in all major body tissues, and are now appreciated to have roles in multiple physiological and pathophysiological processes including diabetes and metabolic diseases, renal, heart, and lung disease, cancer, musculoskeletal disorders, development, human genetic disease, and inflammation and wound healing. The objective of this meeting is to enhance, inspire and accelerate fundamental research and its translational applications in this area by bringing together active researchers and complementary experts who would not otherwise have an opportunity to meet and exchange data, ideas and reagents. Importantly, a goal of this conference is to further the development of young scientists in the field by engaging them through meaningful interactions with both basic and clinical scientists and exposing them to the field in its broadest context.