FASEB SRC on Matricellular Proteins in Development, Health, and Disease

描述（由申请人提供）：细胞与其周围细胞外基质（ECM）之间的相互作用是多细胞生命的基础，也是所有后生动物中细胞和组织组织的必要条件。结构ECM成分，如胶原、纤维连接蛋白和层粘连蛋白，由细胞分泌，并在细胞外组装成有组织的薄片（基底膜）或三维原纤维和网络（结缔组织基质）。ECM还含有较少但高度调控的成分，这些成分在控制细胞行为和基质重塑中起重要作用。由于它们在ECM中的独特定位和功能属性，这些蛋白被称为基质细胞蛋白，包括血栓反应蛋白、CCN、腱蛋白、骨桥蛋白、骨膜蛋白、纤维蛋白和SPARC家族的成员。本次会议的目的是关注这些基质细胞蛋白，并研究它们的结构-功能关系及其对信号网络的影响，这些信号网络在疾病、体内平衡、修复和发育中起着关键作用。通过讲座和海报会议，知名科学家和年轻研究人员将讨论当前的主题，如基质细胞蛋白结构、基因调控、哺乳动物和非哺乳动物模型系统发育中的作用以及对生长因子的影响。这些功能将在它们在组织重塑，炎症，纤维化，损伤/应激反应，发育，神经生物学，代谢调节，血管生成和免疫中的作用的背景下进行检查。该项目将强调炎症和免疫、纤维化、糖尿病和肥胖、心血管疾病、癌症、神经系统和肌肉骨骼疾病的基础和转化应用。该计划将包括邀请演讲者的长篇演讲，从抽象提交中选出的由年轻科学家参加的简短演讲，以及强有力的海报会议。在制定该计划时，强调了妇女、少数民族和年轻科学家的参与。特邀演讲者代表了基础科学领域的领导者、正在定义基质细胞蛋白在遗传性疾病和获得性疾病中的作用的临床研究人员以及研究人员

DESCRIPTION (provided by applicant): Interactions between cells and their surrounding extracellular matrix (ECM) are the basis for multi-cellular life and essential for cell and tissue organization in all metazoan organisms. Structural ECM components such as collagens, fibronectin, and laminins, are secreted by cells and assembled extracellularly into organized sheets (basement membranes) or three-dimensional fibrils and networks (connective tissue matrix). ECM also contains less abundant, but highly regulated, components that play important roles in controlling cell behavior and matrix remodeling. Because of their distinctive localization and functional attributes in the ECM, these proteins have been termed matricellular proteins and include members of the thrombospondin, CCN, tenascin, osteopontin, periostin, fibulin, and SPARC families. The purpose of this conference is to focus on these matriceullular proteins and to examine their structure-function relationships and their impact on signaling networks that play key roles in disease, homeostasis, repair, and development. Through lectures and poster sessions, established scientists and young investigators will address current topics in matricellular protein structure, gene regulation, roles in development in mammalian and non-mammalian model systems, and impact on growth factors. These functions will be examined in the context of their roles in tissue remodeling, inflammation, fibrosis, injury/stress responses, development, neurobiology, metabolic regulation, angiogenesis, and immunity. The program will emphasize basic and translational applications to inflammation and immunity, fibrosis, diabetes and obesity, cardiovascular disease, cancer, neurologic, and musculoskeletal diseases. The program will feature full length talks from invited speakers, short talks selected from abstract submissions which will feature young scientists, and robust poster sessions. Inclusion of women, minorities, and young scientists has been emphasized in developing the program. Invited speakers represent leaders in the basic sciences, clinical investigators who are defining the roles of matricellular proteins in inherited disorders and acquired diseases, and investigators developing novel therapeutics to treat these diseases. The overall objectives of this meeting are to foster new knowledge in the field of matricellular proteins that will lead to development of therapeutics for the treatment of human diseases, facilitate the development of new multidisciplinary collaborations and research directions, and encourage the development of young scientists in this field.