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FASEB SRC on Matricellular Proteins in Development, Health, and Disease

FASEB SRC 关于基质细胞蛋白在发育、健康和疾病中的作用

基本信息

批准号：
8597731
负责人：
JOANNE E MURPHY-ULLRICH
金额：
$ 0.4万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-24 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8597731
关键词：
Academy Address Adhesions Advertising American Animal Model Area Basement membrane Basic Science Biochemical Biological Models Biology Cardiovascular Diseases Cardiovascular system Cell Communication Cells Clinical Investigator Clinical Trials Collaborations Collagen Complex Connective Tissue Cysteine Development Diabetes Mellitus Disabled Persons Disease Drug usage Ensure Epigenetic Process Equilibrium Extracellular Matrix Extracellular Matrix Proteins Family Fibronectins Fibrosis Fishes Fostering Fund Raising Gene Expression Regulation Goals Growth Factor Health Hemostatic function Homeostasis Human Human Genetics Human Pathology Immunity In Vitro Inborn Genetic Diseases Inflammation Injury Interdisciplinary Study International Knowledge Laboratories Laminin Lead Length Life Malignant Neoplasms Metabolic Minority Musculoskeletal Development Musculoskeletal Diseases Neurobiology Neurologic Obesity Organism Phenotype Play Program Development Proteins Publications Regulation Research Research Personnel Rivers Role Science Scientist Signal Transduction Site Structure Structure-Activity Relationship Tenascin Thrombospondins Time Tissues Transportation Vermont Woman Work abstracting angiogenesis base biological adaptation to stress carcinogenesis career cell behavior cell growth regulation clinical application design disability experience fibulin handicapping condition human disease innovation interest lectures meetings member mimetics novel novel therapeutics osteopontin painful neuropathy periostin posters programs protein function protein structure public health relevance receptor repaired symposium synaptogenesis therapeutic development therapeutic target

项目摘要

DESCRIPTION (provided by applicant): Interactions between cells and their surrounding extracellular matrix (ECM) are the basis for multi-cellular life and essential for cell and tissue organization in all metazoan organisms. Structural ECM components such as collagens, fibronectin, and laminins, are secreted by cells and assembled extracellularly into organized sheets (basement membranes) or three-dimensional fibrils and networks (connective tissue matrix). ECM also contains less abundant, but highly regulated, components that play important roles in controlling cell behavior and matrix remodeling. Because of their distinctive localization and functional attributes in the ECM, these proteins have been termed matricellular proteins and include members of the thrombospondin, CCN, tenascin, osteopontin, periostin, fibulin, and SPARC families. The purpose of this conference is to focus on these matriceullular proteins and to examine their structure-function relationships and their impact on signaling networks that play key roles in disease, homeostasis, repair, and development. Through lectures and poster sessions, established scientists and young investigators will address current topics in matricellular protein structure, gene regulation, roles in development in mammalian and non-mammalian model systems, and impact on growth factors. These functions will be examined in the context of their roles in tissue remodeling, inflammation, fibrosis, injury/stress responses, development, neurobiology, metabolic regulation, angiogenesis, and immunity. The program will emphasize basic and translational applications to inflammation and immunity, fibrosis, diabetes and obesity, cardiovascular disease, cancer, neurologic, and musculoskeletal diseases. The program will feature full length talks from invited speakers, short talks selected from abstract submissions which will feature young scientists, and robust poster sessions. Inclusion of women, minorities, and young scientists has been emphasized in developing the program. Invited speakers represent leaders in the basic sciences, clinical investigators who are defining the roles of matricellular proteins in inherited disorders and acquired diseases, and investigators developing novel therapeutics to treat these diseases. The overall objectives of this meeting are to foster new knowledge in the field of matricellular proteins that will lead to development of therapeutics for the treatment of human diseases, facilitate the development of new multidisciplinary collaborations and research directions, and encourage the development of young scientists in this field.

描述（由申请人提供）：细胞与其周围细胞外基质（ECM）之间的相互作用是多细胞生命的基础，对所有后生动物生物体中的细胞和组织组织至关重要。结构ECM组分如胶原蛋白、纤连蛋白和层粘连蛋白由细胞分泌并在细胞外组装成有组织的片（基底膜）或三维原纤维和网络（结缔组织基质）。ECM还含有不太丰富但高度调节的组分，其在控制细胞行为和基质重塑中起重要作用。由于它们在ECM中的独特定位和功能属性，这些蛋白质被称为基质细胞蛋白，并且包括血小板反应蛋白、CCN、腱生蛋白、骨桥蛋白、骨膜蛋白、纤蛋白和骨桥蛋白家族的成员。本次会议的目的是集中在这些matriceullular蛋白，并检查它们的结构-功能关系及其对信号网络的影响，在疾病，稳态，修复和发展中发挥关键作用。通过讲座和海报会议，建立科学家和年轻的研究人员将解决当前的主题在matricellular蛋白质结构，基因调控，在哺乳动物和非哺乳动物模型系统的发展中的作用，以及对生长因子的影响。这些功能将在其在组织重塑，炎症，纤维化，损伤/应激反应，发育，神经生物学，代谢调节，血管生成和免疫中的作用的背景下进行检查。该计划将强调炎症和免疫，纤维化，糖尿病和肥胖，心血管疾病，癌症，神经系统和肌肉骨骼疾病的基本和翻译应用。该计划将包括来自受邀演讲者的完整演讲，从年轻科学家的摘要提交中选择的简短演讲，以及强大的海报会议。在制定该计划时强调了妇女、少数民族和青年科学家的参与。受邀演讲者代表了基础科学的领导者，临床研究人员，他们正在定义基质细胞蛋白在遗传性疾病和获得性疾病中的作用，开发新的疗法来治疗这些疾病。本次会议的总体目标是促进在matricellular蛋白领域的新知识，这将导致治疗人类疾病的治疗方法的发展，促进新的多学科合作和研究方向的发展，并鼓励年轻科学家在这一领域的发展。