FASEB SRC on Matricellular Proteins in Development, Health, and Disease

描述(申请人提供)：细胞与其周围的细胞外基质(ECM)之间的相互作用是所有后生生物中多细胞生命的基础，也是细胞和组织组织所必需的。结构ECM成分，如胶原蛋白、纤维连接蛋白和层粘连蛋白，由细胞分泌，并在细胞外组装成有组织的薄片(基底膜)或三维纤维和网络(结缔组织基质)。ECM还含有含量较少但受高度调控的成分，这些成分在控制细胞行为和基质重塑方面发挥着重要作用。由于它们在细胞外基质中的独特定位和功能属性，这些蛋白被称为基质细胞蛋白，包括血栓反应蛋白、CCN、Tenascin、骨桥蛋白、Periostin、fibulin和SPARC家族的成员。本次会议的目的是集中于这些基质髓蛋白，并研究它们的结构-功能关系以及它们对信号网络的影响，这些信号网络在疾病、内稳态、修复和发育中发挥关键作用。通过讲座和海报会议，知名科学家和年轻的研究人员将讨论母细胞蛋白结构、基因调控、在哺乳动物和非哺乳动物模型系统中的发育中的作用以及对生长因子的影响等当前主题。这些功能将从它们在组织重建、炎症、纤维化、损伤/应激反应、发育、神经生物学、代谢调节、血管生成和免疫中的作用来研究。该计划将侧重于炎症和免疫、纤维化、糖尿病和肥胖症、心血管疾病、癌症、神经学和肌肉骨骼疾病的基础和翻译应用。该节目将包括受邀演讲者的长篇演讲，从以年轻科学家为特色的摘要投稿中挑选的简短演讲，以及活跃的海报会议。在制定该计划时，强调纳入女性、少数民族和年轻科学家。被邀请的演讲者代表基础科学领域的领导者、正在确定基质细胞蛋白在遗传性疾病和获得性疾病中的作用的临床研究人员以及研究人员。 开发治疗这些疾病的新疗法。这次会议的总体目标是培养基质细胞蛋白领域的新知识，这将导致人类疾病治疗疗法的发展，促进新的多学科合作和研究方向的发展，并鼓励该领域的青年科学家的发展。

DESCRIPTION (provided by applicant): Interactions between cells and their surrounding extracellular matrix (ECM) are the basis for multi-cellular life and essential for cell and tissue organization in all metazoan organisms. Structural ECM components such as collagens, fibronectin, and laminins, are secreted by cells and assembled extracellularly into organized sheets (basement membranes) or three-dimensional fibrils and networks (connective tissue matrix). ECM also contains less abundant, but highly regulated, components that play important roles in controlling cell behavior and matrix remodeling. Because of their distinctive localization and functional attributes in the ECM, these proteins have been termed matricellular proteins and include members of the thrombospondin, CCN, tenascin, osteopontin, periostin, fibulin, and SPARC families. The purpose of this conference is to focus on these matriceullular proteins and to examine their structure-function relationships and their impact on signaling networks that play key roles in disease, homeostasis, repair, and development. Through lectures and poster sessions, established scientists and young investigators will address current topics in matricellular protein structure, gene regulation, roles in development in mammalian and non-mammalian model systems, and impact on growth factors. These functions will be examined in the context of their roles in tissue remodeling, inflammation, fibrosis, injury/stress responses, development, neurobiology, metabolic regulation, angiogenesis, and immunity. The program will emphasize basic and translational applications to inflammation and immunity, fibrosis, diabetes and obesity, cardiovascular disease, cancer, neurologic, and musculoskeletal diseases. The program will feature full length talks from invited speakers, short talks selected from abstract submissions which will feature young scientists, and robust poster sessions. Inclusion of women, minorities, and young scientists has been emphasized in developing the program. Invited speakers represent leaders in the basic sciences, clinical investigators who are defining the roles of matricellular proteins in inherited disorders and acquired diseases, and investigators developing novel therapeutics to treat these diseases. The overall objectives of this meeting are to foster new knowledge in the field of matricellular proteins that will lead to development of therapeutics for the treatment of human diseases, facilitate the development of new multidisciplinary collaborations and research directions, and encourage the development of young scientists in this field.