Folic Acid Vitamin B12 and One Carbon Metabolism

描述（由申请人提供）：项目总结/摘要PI Charles H.该提案要求为演讲者和学员提供旅行和注册支持，以参加将于2010年8月1日至6日在亚利桑那州无忧无虑举行的第13届两年一度的FASEB叶酸、维生素B12和一碳代谢夏季研究会议，并为演讲者和学员参加2012年和2014年的两次会议提供旅行支持。会议的总体目标是为该领域的老科学家和新科学家及受训人员提供一个正式和非正式互动的场所。会议的具体目标包括提供最新的激励演示文稿上建立和新兴的主题，并鼓励新的概念和合作的基础和临床科学家在该领域内。该会议于1984年发起，从讨论叶酸和维生素B12在巨幼细胞性贫血，胎儿发育和癌症中的作用发展到现在涵盖了与科学领域快速发展相一致的广泛的基础和临床主题。在为期5天的主题演讲和9个不同的4小时会议，2010年会议将解决基础和临床主题，包括甲基化和表观遗传调控的基因激活在各种疾病，叶酸和维生素B12运输，胎儿发育和出生缺陷，一碳代谢和癌症，高同型半胱氨酸血症和疾病机制，一碳代谢和认知障碍，叶酸和生理痛苦，蛋氨酸代谢的生物化学调节，以及叶酸和维生素B12缺乏症的公共卫生问题讲习班。根据之前的出席情况，预计将有大约150名参与者参加，该计划将包括39名已确认的演讲者和另外12名受训人员和新的研究人员，他们将根据提交的摘要质量被选中进行简短的演讲。此外，还将举办两次海报展示会和两次特别午餐会，供学员与会议主席高级科学家进行互动。这个两年一度的会议通过激发新的研究思路，加强基础和临床科学家之间的合作，吸引新的研究人员和计划中的当前和未来的会议将继续这一传统，对该领域产生了重大影响。 公共卫生相关性：项目叙述PI：Charles H.该提案要求每年提供35,000美元，用于支付部分发言人和受训人员的差旅费和注册费，以参加将于2010年在亚利桑那州无忧无虑举行的FASEB叶酸、维生素B12和一碳物质夏季研究会议，以及2012年和2014年举行的另外两次会议。每个为期5天的会议将基础和临床科学家聚集在一起，以激发该领域各个方面的最新演讲，并鼓励新的概念和新的研究人员和学员之间的合作。该领域涉及蛋氨酸和同型半胱氨酸代谢，疾病过程的遗传和表观遗传调节，以及对包括癌症，出生缺陷，认知障碍，脂质紊乱，肝脏和心血管疾病在内的疾病的新治疗方法的理解和开发。

DESCRIPTION (provided by applicant): Project Summary/Abstract PI Charles H. Halsted The proposal requests travel and registration support for speakers and trainees to attend the 13th biennial FASEB Summer Research Conference on Folic Acid, Vitamin B12, and One-Carbon metabolism which will be held August 1-6, 2010 at Carefree, Arizona, and for travel support for speakers and trainees to attend the two succeeding conferences in 2012 and 2014. The overall goal of the conference is to provide a venue for formal and informal interactions among established and new scientists and trainees in the field. The specific aims of the conference include provision of up to date stimulating presentations on established and emerging topics and to encourage new concepts and collaborations among basic and clinical scientists within the field. Initiated in 1984, the conference has evolved from discussions of the roles of folate and vitamin B12 in megaloblastic anemias, fetal development, and cancer to now cover wide ranges of basic and clinical topics consistent with the rapid evolution of science the field. Over a 5 day period with a keynote and 9 different 4-hour sessions, the 2010 conference will address basic and clinical topics that include methylation and epigenetic regulation of gene activation in varied diseases, folate and vitamin B12 transport, fetal development and birth defects, one- carbon metabolism and cancer, hyperhomocysteinemia and mechanisms of disease, one carbon metabolism and cognitive disorders, folate and physiologic distress, the biochemical regulation of methionine metabolism, and a workshop on public health aspects of folate and vitamin B12 deficiencies. Based on prior attendance, about 150 participants are expected to attend, and the program will include 39 confirmed speakers and an additional 12 trainees and new investigators who will be selected for short talks based on quality of their abstract submissions. There will be in addition two poster sessions and two special luncheons for interactions of trainees with session chair senior scientists. This biennial conference has been a major influence on the field through stimulating new ideas for research, enhancing collaborations between basic and clinical scientists, and attracting new investigators and the planned current and future conferences will continue this tradition. PUBLIC HEALTH RELEVANCE: Project Narrative PI: Charles H. Halsted, MD The proposal requests $35,000 per year to cover partial speaker and trainee travel and registration costs to attend the FASEB Summer Research Conference on Folic Acid, Vitamin B12, and One-Carbon Substances that will be held in 2010 in Carefree, Arizona and on two other occasions in 2012 and 2014. Each 5-day conference brings basic and clinical scientists together for stimulating up to the date presentations on various aspects of the field and for encouraging new concepts and collaborations among established and new investigators and trainees. The field is relevant to methionine and homocysteine metabolism, genetic and epigenetic regulation of disease processes, and understandings and development of new treatments of diseases that include cancer, birth defects, cognitive disorders, lipid disorders, liver and cardiovascular diseases.