Genetic and Neural Complexity in Psychiatry

描述(申请人提供)：精神病学遗传学领域的最新进展带来了兴奋和紧迫性，以智能地设想和设计下一步，以便向精神疾病的神经生物学提供信息，并制定预防、早期干预或治疗的策略。“精神病学中的遗传和神经复杂性”会议的主要目标是促进对精神病学研究未来的讨论，因为精神病学研究的未来是由遗传学的最新进展和神经科学中新出现的概念和方法塑造的。这次会议将把专家聚集在一起，并开启遗传学家和神经学家之间的对话，以便直接翻译和快速应用最新的发现。计划中的第一次会议将集中在深度测序方法，这将允许发现罕见的高渗透性突变，以及旨在了解其对基因功能的影响的方法，包括小鼠模型的产生。它还将解决新兴的重新编程技术，这些技术允许开发携带特定罕见突变的患者的细胞模型，以及研究其他动物物种的利弊，特别是对非人类灵长类动物的研究。最后，它将强调和讨论破译疾病大脑中的电路和通信的新方法。 公共卫生相关性：这次会议汇集了包括遗传学、神经生物学、细胞和发育生物学以及精神病学在内的一系列学科的杰出专家，以确定重要问题，并为精神病学领域的关键进步设定目标和标准。时机恰到好处，因为精神病学遗传学领域的最新进展要求仔细规划下一步，以便向精神障碍的神经生物学提供信息，并制定预防、早期干预或治疗的策略。

DESCRIPTION (provided by applicant): Recent advances in the field of psychiatric genetics have brought about excitement and urgency to envision and design intelligently the next steps in order to inform the neurobiology of the psychiatric disorders and develop strategies for prevention, early intervention, or treatment. The primary goal of the meeting on the "Genetic and Neural Complexity in Psychiatry" is to facilitate a discussion on the future of research in Psychiatry as it is shaped by the recent advances in genetics and newly emerging concepts and approaches in neuroscience. This meeting will bring together experts and open a dialogue between geneticists and neuroscientists allowing direct translation and speedy application of recent findings. The first planned meeting in the proposed series of 3 bi-annual meetings, will focus on deep sequencing approaches, which will allow discovery of rare, highly penetrant mutations, as well as on approaches designed to understand their impact on gene function, including the generation of mouse models. It will also address emerging reprogramming technologies that allow development of cellular models from patients carrying specific rare mutations as well as the pros and cons of studying additional animal species with particular emphasis on non-human primates. Finally, it will highlight and discuss novel approaches to decipher circuitry and communication in the disease brain. PUBLIC HEALTH RELEVANCE: This meeting brings together pre-eminent experts in a range of disciplines, including genetics, neurobiology, cell and developmental biology, and psychiatry, to identify issues of importance, and set goals and standards for the critical advancement of the field of Psychiatry. The time is opportune, since recent advances in the field of psychiatric genetics call for careful planning of the next steps in order to inform the neurobiology of the psychiatric disorders and develop strategies for prevention, early intervention, or treatment.