Hershey Conference on Developmental Brain Injury

描述（由申请人提供）：在胎儿、新生儿和儿童早期，脑血流、代谢和生理紊乱是儿童和成人永久性脑损伤和脑功能障碍的主要原因。由各种损伤和应激引起的产前和围产期脑损伤的动物模型是可用的，并继续为所涉及的关键病理生理、生化和分子过程提供见解。细胞、功能和分子生物学技术已被应用于正常和异常大脑发育的研究。复杂的神经成像技术在人类和动物模型已经允许纵向和动态的研究脑损伤的演变。基因组学和蛋白质组学为基因和药理学干预和神经保护提供了一个额外的维度。在1997年，2000年，2002年，2004年，2006年和2008年举行的六次好时会议不仅在推进科学知识，产生新想法，发展新的合作和推进转化项目方面取得了巨大成功，而且为年轻的研究者提供了巨大的动力。因此，好时会议已经成熟为一个独特的品牌名称，现在已经走向全球。以前会议上的报告已经发表在《发育神经科学》的特刊上，并建立了一个网站来增加与会者之间的互动。要求为第7次会议提供资金，以继续这些会议每两年举行一次，并计划在美国西部地区举行，保持在美国西海岸、东海岸和欧洲交替举行的传统。第八次会议将由欧洲同事组织和资助。第七届会议将延续传统，结合对正常和异常大脑发育不断扩大的理解和最新的评估和干预技术。因此，为期3天的2010年第7届好时会议的主要目标是推进实验室研究向临床治疗的转化，强调需要更好的诊断替代标志物和应用新的令人兴奋的治疗胎儿和新生儿的治疗方法，无论是预防性的还是治疗性的。会议将分为四个领域（替代标记，表观遗传学，祖细胞和生物统计学方法），两个主题（教学和研究）和四种互动类型（讲座，海报，圆桌讨论和非正式）。2010年第7届会议将增加一个新的教学主题，即科学调查的新工具，旨在帮助研究人员熟悉新技术。受邀的主讲人已经承诺参加会议，等待NIH的支持。会议设置的选择将保留之前好时会议的积极属性，因为会议地点将相对独立，有住宿、餐饮和现场会议室，以最大限度地提高参与者之间的非正式互动，并允许年轻的研究人员与高级研究人员和NIH项目官员会面。

DESCRIPTION (provided by applicant): During fetal, neonatal and early childhood, disturbances in cerebral blood flow, metabolism and physiology are major contributors to permanent brain damage and cerebral dysfunction in children and adults. Animal models of prenatal and perinatal brain damage resulting from a variety of insults and stresses are available and continue to provide insight into the key pathophysiological, biochemical and molecular processes involved. Cellular, functional and molecular biological techniques have been applied to the study of normal and abnormal brain development. Sophisticated neuroimaging techniques in both humans and animal models have allowed the longitudinal and dynamic investigation of the evolution of brain injury. Genomics and proteomics offer an added dimension to genetic and pharmacological intervention and neuroprotection. Six previous Hershey Conference meetings held in 1997, 2000, 2002, 2004, 2006 and 2008 have been highly successful in not only advancing scientific knowledge, generating new ideas, developing new collaborations and advancing translational projects but have served as a huge impetus to young investigators. As a result, the Hershey Conference has matured into a unique brand name that has now gone global in its reach. Presentations at previous meetings have been published in special issues of Developmental Neuroscience and a website has been set up to increase interaction between participants. Funding for the 7th meeting is requested to continue these meetings on a biannual basis and is planned to be held in the Western regions of USA, keeping the tradition of alternating locations from West Coast, East Coast of USA and Europe. The 8th meeting will be organized and funded by European colleagues. The 7th meeting will continue the tradition of combining the ever-expanding understanding of normal and abnormal brain development with the most up-to-date techniques for evaluation and intervention. Accordingly, the major goals of the 3-day 2010 7th Hershey Conference are to advance the translation of bench studies to clinical therapies, emphasizing the need for better diagnostic surrogate markers and application of new exciting therapies to fetuses and newborn infants, both preventive and therapeutic in nature. The conference will be divided into four areas (surrogate markers, epigenetics, progenitor cells, and biostatistical approaches), two themes (didactic and investigational), and four types of interaction (lectures, posters, round-table discussion and informal). A new didactic theme will be added to the 2010 7th meeting, New Tools for Scientific Investigation that is aimed at helping investigators become familiar with new techniques. The invited keynote speakers have already committed to the conference, pending NIH support. The choice of the setting for the meeting will preserve the positive attributes of the previous Hershey meetings in that the meeting site will be relatively self-contained with accommodations, meals and meeting rooms on site to maximize informal interaction among participants and allow young investigators to meet with senior investigators and NIH program officials. PUBLIC HEALTH RELEVANCE: The Hershey Conference on Developmental Injury has an indirect but significant impact on public health by providing a major impetus to international collaboration, stimulating new ideas, evaluating therapies for brain injury in the developmental period and encouraging new and better trials for therapies. Because of its emphasis on the newborn infant and young children, the potential impact to the burden of disease is the greatest. Any advances made as a result of the conference may have an impact on the entire life span.