2010 Neural Development Gordon Research Conference

描述（由申请人提供）：神经系统的复杂功能需要高度协调和精确调节的发育程序。这些程序的改变已被证明是许多神经疾病的基础，包括自闭症、行为综合征和神经变性。因此，全面了解神经系统发育的基本机制对于合理设计治疗和行为策略来对抗这些疾病至关重要。2010年神经发育戈登研究会议的目标是将现有的和新兴的研究人员聚集在一起，讨论最近的研究突破，以促进互动和合作，并加强转化研究的基础。会议的总体主题将围绕分子遗传学方法，以及跨物种研究在我们对神经发育原理的理解中的作用。自1981年以来，该会议每两年举行一次，并已成为该领域的主要会议，始终吸引着杰出的国内和国际研究人员，以及学生和博士后，在一个小型，互动的环境中进行深入的科学讨论。会议的形式以口头陈述为中心，然后是广泛的讨论，高度互动的海报会议，以及非正式会议的“自由”时间，这使得互动的水平和深度在其他大型会议中很少发现。2010年会议将涵盖9个主题，包括大脑模式；神经干细胞；细胞命运规范;神经元的形态、模式和生长；突触的发展;关键技术突破；神经元基因表达调控；电路的开发；退化和再生。在开发该计划时，我们注意到邀请了最近取得令人兴奋的突破的演讲者，他们在研究中使用了各种模型系统和多种方法，包括分子，遗传和细胞。该项目还包括国内和国际演讲者，以及高级和初级研究人员。已确认的演讲者中有41%是女性。基于以往的历史，我们期望2010神经发育GRC在进一步加深我们对神经元发育的理解，并促进解决人类神经发育病理学的转化研究策略方面取得同样的成功。

DESCRIPTION (provided by applicant): The complex functions carried out by the nervous system demand highly orchestrated and precisely regulated developmental programs. Alterations in these programs have been shown to underlie many neuronal disorders including autism, behavioral syndromes, and neurodegeneration. Thus, a complete understanding of the basic mechanisms of nervous system development is essential for a rational design of therapeutic and behavioral strategies to combat these disorders. The goal of the 2010 Neural Development Gordon Research conference is to bring together established and rising investigators to discuss recent research breakthroughs, in order to foster interactions and collaborations, and to strengthen the foundation for translational research. The overall theme of the meeting will center around a molecular genetic approach, and the role of cross-species investigations in our understanding of neurodevelopmental principles. This conference has been held biannually since 1981, and has become the premier conference in this field that consistently attracts prominent national and international researchers, as well as students and postdoctoral fellows in a small, interactive setting for in depth scientific discussions. The format of the meeting which is centered around oral presentations followed by extensive discussions, highly interactive poster sessions, and 'free' time for informal meetings allows a level and depth of interaction that is rarely found at other, larger conferences. The 2010 conference will cover 9 themes including brain patterning; neuronal stem cells; cell fate specification; neuronal morphology, patterning and outgrowth; synaptic development; key technological breakthroughs; regulation of neuronal gene expression; development of circuits; and degeneration and regeneration. In developing the program, attention was paid to inviting speakers who have made recent exciting breakthroughs and who use a variety of model systems and multiple approaches including molecular, genetic and cellular, in their research. The program also includes national and international speakers, as well as both senior and junior researchers. 41% of the confirmed speakers are women. Based on prior history, we expect that the 2010 Neural Development GRC will be similarly successful in furthering our understanding of neuronal development, and in promoting strategies for translational research to address human neurodevelopmental pathologies. PUBLIC HEALTH RELEVANCE: Research conferences provide a critical forum for the dissemination of research findings, and for the establishment of collaborations leading to novel insights. The 2010 Gordon Research Conference in Neural Development is expected to impact public health by furthering our understanding of the basic mechanisms by which the central and peripheral nervous systems develop, and how these mechanisms are disrupted in diseases. Discussions and interactions among researchers working on different model systems using multiple experimental approaches is expected to result in the initiation of novel research directions, leading to the development of new therapeutic strategies and the identification of targets for rational drug design.