N-DEMETHYLATION IS A MAJOR ROUTE OF 2-AMINO-3-METHYLIMIDAZO[4,5-F]

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 为了更好地了解2-氨基-3-甲基咪唑并[4，5-f]喹啉(IQ)的致瘤性，对其在小鼠体内的代谢进行了研究。将口服40 mg/kg[(14)C]IQ的小鼠的尿代谢物与类似处理的大鼠的尿代谢物进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) metabolism was evaluated in mouse to better understand its tumorigenicity. Urinary metabolites from mice orally administered 40 mg/kg [(14)C]IQ were compared with those from similarly treated rats.