课题基金 / 基金详情

Chromatin Remodeling and Transcription Repression

Chromatin Remodeling and Transcription Repression
染色质重塑和转录抑制
批准号：
7995660
负责人：
Blaine Bartholomew
金额：
$14.13万
依托单位：
SOUTHERN ILLINOIS UNIVERSITY CARBONDALE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-02-12 至 2010-12-31
来源：
https://reporter.nih.gov/project-details/7995660
关键词：
ATPase DomainArchitectureBackBiochemicalBiological ProcessCatalytic DomainCellsChromatinChromatin Remodeling FactorChromosomesCodeComplexDNADNA PackagingDeletion MutagenesisDeletion MutationDevelopmentGene ExpressionGenesGenetic TechniquesGenomicsGoalsHealthHistonesISWIISWI Family ProteinIn VitroMediatingMethodsMolecularMolecular GeneticsNucleosomesProcessPropertyProteinsRNA Polymerase IIRNA chemical synthesisReadingRegulationRepressionRoleSeriesSiteSmall Interfering RNAStagingStem cellsStructureTechniquesTertiary Protein StructureTranscription ElongationUntranslated RNAcell typecellular developmentchromatin remodelingcrosslinkdomain mappingenzyme activitygene repressiongenetic analysishistone modificationin vivomacromolecular assemblymutantnovelprotein protein interactionrepairedtumorigenesisyeast genetics

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中文摘要
翻译
项目总结： ISWI型染色质重塑复合体已被证明参与了 转录抑制，以及转录延伸和终止的调节。 染色质和染色体区域的重组是细胞的基础 发展与差异化。我们建议进一步加深对这些问题的理解 通过双管齐下的方法：(1)广泛的生物化学表征 ISWI蛋白家族；(2)突变型与野生型的分子遗传分析 体内存在ISWI复合体。
英文摘要
Project Summary: The ISWI type chromatin remodeling complexes have been shown to be involved in transcription repression, and the regulation of transcription elongation and termination. Reorganization of chromatin and regions in chromosomes are fundamental in cellular development and differentiation. We propose to further our understanding of these processes by a two-prong approach of (1) extensive biochemical characterization of the ISWI family of proteins and (2) the molecular genetic analysis of mutant versus wild type ISWI complexes in vivo.
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会议论文
Regulation of RNA polymerase II pausing and directionality by ATP-dependent chromatin remodelers
Regulation of RNA polymerase II pausing and directionality by ATP-dependent chromatin remodelers
Regulation of chromatin organization and dynamics by INO80
The interplay between the chromatin remodeler INO80 and histone variant H2A.Z.
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