Enabling Technologies to Macromolecular Crystallization

结构生物学是研究生物重要分子形状的一门基础科学。 对生命的理解；它主要是单晶衍射研究的结果。项目“使能” “大分子结晶技术”在高通量研究实验室工作基础上的扩展 (HTSlab)，这是纽约州布法罗市豪普特曼-伍德沃德研究所的一家大分子结晶设施。这个 HTSLab专门开发高通量生长大分子晶体的方法 适合于衍射研究；这种晶体的形成是科学中的一个重要瓶颈 结构生物学。我们将继续与普通生物学、结构生物学和结构生物学合作 基因组学小组进行结晶试验，并对多达1000项试验进行分析 每年都有大分子物质。我们将在三个领域开展工作：提供结晶专业知识和 为三个生物界的成员提供服务；结晶的开发和测试 在高吞吐量环境中的方法和材料；以及信息学服务和 用于分析结晶结果的工具。我们希望与PSI社区密切合作，因为它 将其进一步的努力引向对复杂系统生物学的更深入理解。

Structural biology, the study of the shapes of biologically important molecules, is a foundational science in the understanding of life; it is principally the result of single crystal diffraction studies. The project "Enabling Technologies for Macromolecular Crystallization" expands upon the work of the High Throughput Search Lab (HTSlab), a macromolecular crystallization facility at the Hauptman-Woodward Institute in Buffalo, NY. The HTSlab specializes in the development of high throughput methods to grow crystals of macromolecules suitable for diffraction studies; the formation of such crystals is a significant bottleneck in the science of structural biology. We will continue to partner with general biology, structural biology and structural genomics groups to undertake crystallization trials and enable analysis of these trials on as many as 1000 macromolecules each year. We will work in three areas: the provision of crystallization expertise and services for members of the three biology communities; the development and testing of crystallization methods and materials in a high throughput environment; and the integration of informatics services and tools for the analysis of crystallization results. We expect to work closely with the PSI community as it directs its further efforts toward a deeper understanding of the biology of complex systems.