AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Mino

描述(由申请者提供)：这次拟议的会议将是AACR系列会议中的第四次，该系列专门关注癌症健康差异的科学。前几届会议分别于2007年11月27日至30日、2009年2月3日至6日和2010年9月30日至10月3日举行，出席人数每年稳步增长。癌症发病率的种族和民族差异是有据可查的。虽然数据表明，获得高质量的护理有助于癌症的差异，但其他因素也起到了重要作用，包括肿瘤生物学、遗传学、激素状况、生活方式和行为、筛查政策、合并症、环境暴露和风险、治疗质量和反应以及治疗后监测。这次会议和系列会议的目标是将在不同学科工作的科学家和其他专业人员聚集在一起，讨论该领域的最新发现，并刺激癌症健康差异方面的新研究的发展。需要基础科学、临床研究、人口科学、行为研究和癌症生存等多个学科之间的跨学科互动，才能推动该领域向前发展，并在减少和消除与癌症有关的差异方面取得进展。 公共卫生相关性：癌症发病率和死亡统计数据显示，在美国，某些种族和民族群体患有癌症及其相关影响的比例较高。尽管一些差异可以用社会经济因素来解释，但也有生物学基础。例如，研究已经确定了荷尔蒙状态的差异，以及在非裔美国人中更常见的一些BRCA1和BRCA2变体。遗传易感性和致病分子途径的差异被认为是前列腺癌差异的一个来源。有必要将科学家、医生和其他卫生专业人员聚集在一起，促进讨论和合作，推动该领域向前发展，并在减少和消除癌症健康差距方面取得进展。

DESCRIPTION (provided by applicant): This proposed conference will be the fourth in an AACR series focused specifically on the science of cancer health disparities. The previous conferences on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved were held November 27-30, 2007, February 3-6, 2009, and September 30-October 3, 2010 and attendance has steadily grown each year. Racial and ethnic disparities in cancer rates are well documented. While data suggest that access to quality care contributes to cancer disparities, other factors also play a major role, including tumor biology, genetics, hormonal status, lifestyle and behavior, screening policies, comorbidities, environmental exposure and risk, quality of and response to therapy, and post- therapeutic surveillance. The goal of this conference and the conference series is to bring together scientists and other professionals working in a variety of disciplines to discuss the latest findings in the field and to stimulate the development of new research in cancer health disparities. Transdisciplinary interactions between a variety of disciplines including basic science, clinical research, population science, behavioral research, and cancer survivorship, are needed to move the field forward and make progress in reducing and eliminating disparities as they relate to cancer. PUBLIC HEALTH RELEVANCE: Cancer incidence and death statistics show that certain racial and ethnic groups in the United States suffer disproportionately from cancer and its associated effects. Although some disparities may be explained by socioeconomic factors, there is a biological basis as well. For example, research has identified differences in hormonal status and a number of BRCA1 and BRCA2 variants that are more common among African Americans. Differences in inherited susceptibilities and molecular pathways for pathogenesis have been implicated as a source of prostate cancer disparities. There is a need to bring together scientists, physicians, and other health professionals to foster discussions and collaborations that will move the field forward and make progress in reducing and eliminating cancer health disparities.