Tenth Annual AACR International Conference on Frontiers in Cancer Prevention Rese

描述(申请人提供)：第十届癌症预防研究前沿国际年会将于2011年10月22-25日在马萨诸塞州波士顿的波士顿会展中心举行。AACR长期以来一直支持癌症预防研究，旨在通过改变生活方式和早期发现和治疗来预防癌症。这个一年一度的AACR会议系列会议于2002年首次亮相，至今仍是世界上最杰出的癌症预防会议。医生、科学家、患者和幸存者倡导者从该领域领先的基础、临床、流行病学和行为科学家那里了解最新的翻译发现。这次会议促进了跨学科合作，加快了预防研究领域的进展，并促进了人们对癌症预防在降低癌症发病率和死亡率方面的关键重要性的认识。今年会议的主题是“通过技术推进癌症预防”。该计划将突出新技术如何推动癌症预防研究的所有学科，同时也将重点放在如何将这些进步整合到不同学科之间，以有效预防癌症。科学进步正在改变癌症预防领域，为我们提供了所需的信息和技术，以了解人类癌症发生的分子基础，并以前所未有的准确性和有效性识别和干预疾病过程。通过将我们对基础科学的理解转化为临床应用，公共卫生层面正在看到好处。致癌起始和进展中的几个步骤是癌症预防的目标。初级预防是避免接触致癌物或致癌过程，可针对没有表现出癌前症状的广大个人。锻炼和避免吸烟就是这种干预的例子。最成功的初级预防策略之一是开发乙肝疫苗和人乳头状瘤病毒疫苗。二级预防工作受到了极大的关注，包括筛查和早期发现，这些工作通常针对更具体的风险人群。这类预防的例子包括结肠镜检查和息肉切除术。研究发现，癌前病变可能比以前认识到的更常见，了解哪些癌前病变进展为癌症，另一些不进展为癌症将是至关重要的。最后，三级预防的目的是防止复发或第二次癌症。 公共卫生相关性：减少烟草使用和实施人乳头瘤病毒和乙肝疫苗接种等几项主要预防战略已经通过降低癌症发病率和死亡率对全球公共卫生产生重大影响。作为二级预防策略的重要组成部分，多项研究发现，癌前病变也可能比以前认识到的更常见。最近的科学进步为我们提供了必要的信息和技术，以阐明人类癌症发生的分子基础；了解为什么一些癌前病变会发展为癌症，而另一些则不会，这将是个性化治疗和避免患者过度治疗的关键。这一年度会议为科学家、医生和其他健康专业人员提供了一个场所，让他们了解和讨论该领域最尖端的研究，并形成跨学科合作，以加快癌症预防研究的进展。

DESCRIPTION (provided by applicant): The Tenth Annual International Conference on Frontiers in Cancer Prevention Research will take place October 22-25, 2011, at the Boston Convention and Exhibition Center in Boston, Massachusetts. The AACR has long been a supporter of cancer prevention research aimed at preventing cancer through lifestyle changes and early detection and treatment. This annual AACR conference series debuted in 2002 and remains the pre-eminent cancer prevention meeting in the world. Physicians, scientists, patients, and survivor advocates learn about the latest translational discoveries from the leading basic, clinical, epidemiologic, and behavioral scientists in the field. The conference fosters interdisciplinary collaborations, accelerates progression in the field of prevention research, and promotes awareness of the vital importance of cancer prevention in reducing cancer incidence and mortality. This year's conference theme is "advancing cancer prevention through technology." The program will highlight how new technologies have advanced all disciplines of cancer prevention research, while also focusing on how these advances can be integrated across disciplines to effectively prevent cancer. Scientific advances are transforming the field of cancer prevention by providing us with the information and technology needed to understand the molecular underpinnings of carcinogenesis in humans and to identify and intervene in disease processes with unprecedented accuracy and effectiveness. By translating our understanding of the basic science into clinical application, benefits are being seen at the public health level. Several steps within carcinogenic initiation and progression are targets for cancer prevention. Primary prevention is the avoidance of exposure to carcinogens or the carcinogenic process and may be directed at the broad population of individuals who show no sign of premalignancy. Exercise and avoidance of tobacco are examples of this type of intervention. And one of the most successful primary prevention strategies is the development of vaccines such as those for HBV and HPV. Secondary prevention efforts are receiving a lot of attention and include screening and early detection, which are generally directed toward a more specified risk population. Examples of this type of prevention include colonoscopy and polypectomy. Studies have found that premalignant lesions may be more common than previously realized and it will be crucial to understand who some premalignant lesions progress to cancer and others do not. Finally, tertiary prevention is aimed at preventing recurrence or second cancers. PUBLIC HEALTH RELEVANCE: Several primary prevention strategies such as decreasing tobacco use and implementing HPV and HBV vaccination are already having a major impact on global public health by reducing cancer incidence and mortality. Important to secondary prevention strategies, several studies have found that premalignant lesions may also be more common than previously realized. Recent scientific advances are providing us with the information and technology needed to elucidate the molecular underpinnings of carcinogenesis in humans; understanding why some premalignant lesions progress to cancer while others do not will be crucial to personalizing therapy and avoiding overtreatment of patients. This annual conference provides a venue for scientists, physicians, and other health professionals to learn about and discuss the most cutting-edge research in the field and form interdisciplinary collaborations that will accelerate progression in cancer prevention research.