2011 Angiogenesis Gordon Research Conference and Gordon Research Seminar

描述(由申请者提供)：本提案请求对2011年血管生成戈登会议及其附属的年轻科学家戈登研究研讨会提供部分支持，该研讨会将于8月20-26日在罗德岛州纽波特的Salve Regina大学举行。到目前为止，大会已经举办了10年，在该领域有着非常高的地位；通常情况下，它的订阅量严重超额。会议的目标是介绍关于内皮生物学、血管形成、生长、退化和生理和疾病变化的分子细节的一线研究。血管在病理过程中的作用比先前预期的更为复杂。因此，我们需要更好地了解、预测和控制血管生成抑制在疾病治疗中的复杂后果。会议将讨论这方面的一系列重要问题。内皮细胞是否有独特的刺激/反应模式？如何保持船舶的稳定性？血管可塑性能被控制吗？我们将继续讨论与这些重要议题有关的困惑、矛盾和冲突。这一应用的意义在于，这次会议具有非常高的地位，聚集了来自学术界、临床医学和制药行业的年轻和国际知名科学家，专注于血管生成研究中的重要问题及其潜在的解决方案。第一次，血管生成GRC也有一个附属的GRS。这一应用的健康相关性在于，与血管生成分子机制相关的重要问题关系到临床治疗，例如癌症的治疗。 与公共卫生相关：过度和失调的血管生成是癌症等破坏性疾病的标志。尽管抗血管生成药物在临床上得到了应用，但我们对控制血管生成的分子机制仍没有完全的认识。为了血管生成领域持续高质量的研究和快速发展，我们必须有机会进行互动，以解决困惑、悖论和冲突。

DESCRIPTION (provided by applicant): This proposal requests partial support for the 2011 Angiogenesis Gordon Conference and its affiliated Gordon Research Seminar for younger scientists, which will be held at Salve Regina University, Newport, Rhode Island, August 20-26. The conference has been running for 10 years by now and has a very high standing in the field; as a rule, it is heavily over- subscribed. The goal of the conference is to present front-line research on molecular details in endothelial biology, blood vessel formation, growth, regression and alteration in physiology and disease. Vessels contribute to pathological processes in a more complex manner than previously anticipated. We therefore need to better understand, predict and control the complex consequences of angiogenesis inhibition in disease therapy. The conference will discuss a wide spectrum of vital questions in this regard. Do endothelial cells have a unique stimulus/response pattern? How is the stability of the vessel maintained? Can vessel plasticity be controlled? We will continue to discuss the puzzles, paradoxes and conflicts relating to these important topics. The significance of this application is that this conference is of very high stature and brings together young and internationally established scientists from academia, clinical medicine and pharmaceutical industry to focus on important problems and their potential solutions, in angiogenesis research. For the first time, the Angiogenesis GRC also has an affiliated GRS. The health relatedness of this application is that important questions relating to the molecular mechanisms in angiogenesis has a bearing on clinical treatment e.g. of cancer. PUBLIC HEALTH RELEVANCE: Excess and dysregulated angiogenesis is a hallmark of devastating diseases such as cancer. Even though anti-angiogenic drugs are used in the clinic, we still do not have full insights to master the molecular mechanisms controlling angiogenesis. It is essential that we have opportunities for interactions to solve puzzles, paradoxes and conflicts, for the benefit of continued high quality research and rapid development in the field of angiogenesis.